USP9X (FAM) deubiquitinates SMAD4

Stable Identifier
R-HSA-870437
Type
Reaction
Species
Homo sapiens
Compartment
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USP9X (FAM) deubiquitinates SMAD4, thereby opposing the negative regulatory activity of TRIM33 (Ectodermin) (Dupont et al. 2009).

Literature References
PubMed ID Title Journal Year
19135894 FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

Stinchfield, MJ, Montagner, M, Morsut, L, Piccolo, S, Inui, M, Moro, S, Mamidi, A, Newfeld, SJ, Soligo, S, Dupont, S, Argenton, F, Martello, G, Modena, N, Adorno, M, Zacchigna, L, Cordenonsi, M

Cell 2009
Participants
Participates
Catalyst Activity

thiol-dependent deubiquitinase activity of Ub-SMAD4:USP9X [cytosol]

Orthologous Events
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