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RASGRP1 [cytosol]
Stable Identifier
R-HSA-870270
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CalDAG-GEFII, RAS guanyl-releasing protein 1, GRP1_HUMAN, RasGRP
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) (Homo sapiens)
CalDAG-GEFs [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Homo sapiens)
CalDAG-GEFs [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
Activation of Rap1 by cytosolic GEFs (Homo sapiens)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Homo sapiens)
CalDAG-GEFs [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Rap1 signalling (Homo sapiens)
Activation of Rap1 by cytosolic GEFs (Homo sapiens)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Homo sapiens)
CalDAG-GEFs [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of RAS in B cells (Homo sapiens)
RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated (Homo sapiens)
RASGRP1,3 [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
RasGRP interacts with DAG and Ca2+ (Homo sapiens)
RasGRPs [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
RasGRPs:DAG:Ca2+ [plasma membrane] (Homo sapiens)
RasGRPs [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
Activation of Rap1 by cytosolic GEFs (Homo sapiens)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Homo sapiens)
CalDAG-GEFs [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) (Homo sapiens)
CalDAG-GEFs [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
CalDAG-GEFs:DAG:Ca2+ [plasma membrane] (Homo sapiens)
CalDAG-GEFs [cytosol] (Homo sapiens)
RASGRP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95267 RASGRP1
Gene Names
RASGRP1, RASGRP
Chain
chain:1-797
Reference Genes
BioGPS Gene:10125 RASGRP1
COSMIC (genes):RASGRP1 RASGRP1
CTD Gene:10125 RASGRP1
dbSNP Gene:10125 RASGRP1
ENSEMBL:ENSG00000172575 RASGRP1
HGNC:9878 RASGRP1
KEGG:hsa:10125 RASGRP1
Monarch:10125 RASGRP1
NCBI Gene:10125 RASGRP1
OMIM:603962 RASGRP1
UCSC:O95267 RASGRP1
Reference Transcript
RefSeq:NM_001306086.1 RASGRP1
RefSeq:NM_001128602.1 RASGRP1
RefSeq:NM_005739.3 RASGRP1
Other Identifiers
10125
11728920_a_at
11740370_a_at
11747558_a_at
11750397_a_at
11752528_a_at
16807195
205590_PM_at
205590_at
33291_at
3618735
3618737
3618738
3618739
3618740
3618741
3618742
3618743
3618744
3618745
3618746
3618747
3618748
3618749
3618750
3618751
3618752
3618753
3618755
3618756
3618757
3618758
3618759
3618760
3618761
3618762
3618763
3618765
3618775
3618777
3618778
3618779
3618780
3618781
3618782
3618783
3618784
7987405
A_23_P113258
A_23_P124642
A_32_P195478
GE482493
GE81550
GO:0000139
GO:0001934
GO:0002376
GO:0002437
GO:0005085
GO:0005509
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005886
GO:0006954
GO:0007018
GO:0007165
GO:0007264
GO:0007265
GO:0008270
GO:0008289
GO:0016020
GO:0016192
GO:0019992
GO:0030101
GO:0030154
GO:0031210
GO:0032252
GO:0032816
GO:0032825
GO:0033089
GO:0042098
GO:0042100
GO:0042110
GO:0042113
GO:0042802
GO:0043226
GO:0043303
GO:0043406
GO:0045954
GO:0046579
GO:0046872
GO:0047496
GO:0051896
GO:0070372
GO:0090630
GO:0098772
HMNXSV003001786
ILMN_1768958
PH_hs_0022905
TC15001217.hg
g6382080_3p_at
Participates
as a member of
CalDAG-GEFs [cytosol] (Homo sapiens)
RasGRPs [cytosol] (Homo sapiens)
RASGRP1,3 [cytosol] (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-T184-RASGRP1 [plasma membrane]
Inferred To
gefW [cytosol]
(Dictyostelium discoideum)
rasgrp1 [cytosol]
(Xenopus tropicalis)
CDC25 [cytosol]
(Saccharomyces cerevisiae)
LTE1 [cytosol]
(Saccharomyces cerevisiae)
gefP [cytosol]
(Dictyostelium discoideum)
BUD5 [cytosol]
(Saccharomyces cerevisiae)
Homologues of RASGRP1 [cytosol]
(Dictyostelium discoideum)
Homologues of RASGRP1 [cytosol]
(Saccharomyces cerevisiae)
rgef-1 [cytosol]
(Caenorhabditis elegans)
RASGRP1 [cytosol]
(Bos taurus)
RASGRP1 [cytosol]
(Canis familiaris)
RASGRP1 [cytosol]
(Gallus gallus)
RASGRP1 [cytosol]
(Mus musculus)
RASGRP1 [cytosol]
(Rattus norvegicus)
RASGRP1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001293015.1
,
NP_005730.2
,
NP_001122074.1
Guide to Pharmacology - Targets
3016
ENSEMBL
ENSP00000452721
,
ENSP00000388540
,
ENSP00000413105
,
ENSP00000454164
,
ENST00000414708
,
ENST00000559830
,
ENST00000450598
,
ENST00000558164
,
ENST00000310803
,
ENSP00000310244
OpenTargets
ENSG00000172575
ZINC - Substances
GRP1_HUMAN
ZINC target
O95267
PRO
O95267
PDB
4L9M
,
4L9U
HPA
ENSG00000172575-RASGRP1
Pharos - Targets
O95267
Orphanet
RASGRP1
ZINC - Predictions - Purchasable
GRP1_HUMAN
HMDB Protein
HMDBP07719
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