Gastrin binds to CCK-B receptor

Stable Identifier
R-HSA-870269
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Gastrin binds to CCK-B receptor
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Gastrin receptors (gastric cholecystokinin B receptor, CCK-BR) mediate acid secretion from parietal cells, release of histamine from enterochromaffin-like (ECL) cells and contraction of smooth muscle (Ito et al. 1993).The hormone gastrin is the central regulator of gastric acid secretion and in addition, plays a prominent role in regulation of growth and differentiation of gastric and colonic mucosa.

Literature References
PubMed ID Title Journal Year
8349705 Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin

Chiba, T, Taniguchi, T, Tsukamoto, T, Murayama, T, Matsui, T, Nakata, H, Ito, M, Chihara, K, Arima, N

J Biol Chem 1993
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Orthologous Events
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Gastrin binds to CCK-B receptor (Canis familiaris)
Gastrin binds to CCK-B receptor (Mus musculus)
Gastrin binds to CCK-B receptor (Rattus norvegicus)
Authored
Tripathi, S  (2012-04-04)
Jassal, B  (2012-04-04)
Reviewed
D'Eustachio, P  (2012-04-23)
Created
Jassal, B  (2010-06-07)
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