Gastrin binds to CCK-B receptor

Stable Identifier
R-HSA-870269
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Gastrin receptors (gastric cholecystokinin B receptor, CCK-BR) mediate acid secretion from parietal cells, release of histamine from enterochromaffin-like (ECL) cells and contraction of smooth muscle (Ito et al. 1993).The hormone gastrin is the central regulator of gastric acid secretion and in addition, plays a prominent role in regulation of growth and differentiation of gastric and colonic mucosa.

Literature References
PubMed ID Title Journal Year
8349705 Functional characterization of a human brain cholecystokinin-B receptor. A trophic effect of cholecystokinin and gastrin

Ito, M, Matsui, T, Taniguchi, T, Tsukamoto, T, Murayama, T, Arima, N, Nakata, H, Chiba, T, Chihara, K

J Biol Chem 1993
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