AIM2 binds dsDNA

Stable Identifier
R-HSA-844619
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AIM2 binds dsDNA
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AIM2 binds to cytosolic dsDNA via its C-terminal HIN domain. The source of the dsDNA can be can be viral, bacterial or derived from the host (Hornung et al. 2009, Muruve et al. 2008). Multiple AIM2 molecules may bind the same dsDNA (Fernandes-Alnemri et al. 2008).
Literature References
PubMed ID Title Journal Year
19158675 AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V, Ablasser, A, Charrel-Dennis, M, Bauernfeind, FG, Horvath, G, Caffrey, DR, Latz, E, Fitzgerald, KA

Nature 2009
19158676 AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T, Yu, JW, Datta, P, Wu, J, Alnemri, ES

Nature 2009
19158679 An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Burckstummer, T, Baumann, C, Bluml, S, Dixit, E, Durnberger, G, Jahn, H, Planyavsky, M, Bilban, M, Colinge, J, Bennett, KL, Superti-Furga, G

Nat Immunol 2009
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Orthologous Events
AIM2 binds dsDNA (Mus musculus)
AIM2 binds dsDNA (Rattus norvegicus)
Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-05-28)
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