AIM2 binds to cytosolic dsDNA via its C-terminal HIN domain. The source of the dsDNA can be can be viral, bacterial or derived from the host (Hornung et al. 2009, Muruve et al. 2008). Multiple AIM2 molecules may bind the same dsDNA (Fernandes-Alnemri et al. 2008).
Fernandes-Alnemri, T, Yu, JW, Datta, P, Wu, J, Alnemri, ES
Hornung, V, Ablasser, A, Charrel-Dennis, M, Bauernfeind, FG, Horvath, G, Caffrey, DR, Latz, E, Fitzgerald, KA
Burckstummer, T, Baumann, C, Bluml, S, Dixit, E, Durnberger, G, Jahn, H, Planyavsky, M, Bilban, M, Colinge, J, Bennett, KL, Superti-Furga, G
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