The AIM2 inflammasome

Stable Identifier
R-HSA-844615
Type
Pathway
Species
Homo sapiens
Compartment
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AIM2 is a member of the PYHIN or HIN200 family. It has a C-terminal HIN domain which can bind double-stranded DNA (dsDNA) and a PYD domain that can bind ASC via a PYD-PYD interaction. In cells expressing procaspase-1, The interaction of AIM2 with ASC leads to recruitment of procaspase-1 forming the ASC pyroptosome which induces pyroptotic cell death by generating active caspase-1. Data from AIM2 deficient mice indicates that the AIM2 inflammasome is a nonredundant sensor for dsDNA that regulates the caspase-1-dependent maturation of IL-1beta and IL-18 (Rathinam et al. 2010, Hornung & Latz, 2009).

Literature References
PubMed ID Title Journal Year
20303873 The inflammasomes

Schroder, K, Tschopp, J

Cell 2010
Participants
Participant Of
hasEvent
Orthologous Events
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Created