Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
POLR2L [nucleoplasm]
Stable Identifier
R-HSA-83715
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HsRPABC5, DNA-directed RNA polymerase II 7.6 kDa polypeptide (EC 2.7.7.6) (RPB10) (RPB7.6), DNA-directed RNA polymerase II 7.6 kDa polypeptide , RPB10, RPB7.6, RPABC5
Locations in the PathwayBrowser for interactor UniProt:P0DPB6 RPAC2
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
POLR2L [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62875 POLR2L
Gene Names
POLR2L
Chain
chain:1-67
Reference Genes
BioGPS Gene:5441 POLR2L
COSMIC (genes):POLR2L POLR2L
CTD Gene:5441 POLR2L
dbSNP Gene:5441 POLR2L
ENSEMBL:ENSG00000177700 POLR2L
HGNC:9199 POLR2L
KEGG:hsa:5441 POLR2L
Monarch:5441 POLR2L
NCBI Gene:5441 POLR2L
OMIM:601189 POLR2L
UCSC:P62875 POLR2L
Reference Transcript
RefSeq:NM_021128.4 POLR2L
Other Identifiers
11716442_a_at
11753875_a_at
11753876_x_at
16734154
202586_PM_at
202586_at
211730_PM_s_at
211730_s_at
3358494
3358495
3358498
3358499
3358500
35841_at
503_at
5441
78238_at
7945573
A_23_P33015
GE79031
GO:0000428
GO:0001054
GO:0001055
GO:0001056
GO:0003677
GO:0003824
GO:0003899
GO:0005515
GO:0005634
GO:0005654
GO:0005665
GO:0005666
GO:0005730
GO:0005736
GO:0005829
GO:0006351
GO:0006355
GO:0006356
GO:0006360
GO:0006366
GO:0006399
GO:0008270
GO:0016740
GO:0042797
GO:0043226
GO:0046872
GO:0140098
HMNXSV003013515
Hs.71618.0.S2_3p_at
ILMN_1670037
TC11001251.hg
U37690_at
g13543491_3p_s_at
Participates
as a component of
RNA Polymerase III Holoenzyme [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (p-Ser2,7 CTD) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (p-Ser5,7 CTD) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Homo sapiens)
Ubiquitinated RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex phosphorylated by CDK12 [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (hyperphosphorylated) [nucleoplasm] (Homo sapiens)
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm] (Homo sapiens)
as an input of
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
Other forms of this molecule
POLR2L [cytosol]
Inferred To
polr2l [nucleoplasm]
(Danio rerio)
polr2l [nucleoplasm]
(Xenopus tropicalis)
AC109542.1 [nucleoplasm]
(Rattus norvegicus)
POLR2L [nucleoplasm]
(Bos taurus)
POLR2L [nucleoplasm]
(Caenorhabditis elegans)
POLR2L [nucleoplasm]
(Canis familiaris)
POLR2L [nucleoplasm]
(Dictyostelium discoideum)
POLR2L [nucleoplasm]
(Drosophila melanogaster)
POLR2L [nucleoplasm]
(Gallus gallus)
POLR2L [nucleoplasm]
(Mus musculus)
POLR2L [nucleoplasm]
(Plasmodium falciparum)
POLR2L [nucleoplasm]
(Saccharomyces cerevisiae)
POLR2L [nucleoplasm]
(Schizosaccharomyces pombe)
POLR2L [nucleoplasm]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000177700
ENSEMBL
ENSP00000432807
,
ENST00000534030
,
ENSP00000324124
,
ENSG00000177700
,
ENST00000322028
GeneCards
POLR2L
HPA
ENSG00000177700-POLR2L
PRO
P62875
Pharos - Targets
P62875
HMDB Protein
HMDBP11915
PDB
7FJJ
,
7FJI
,
7AE1
,
7A6H
,
7DU2
,
7AE3
,
8IUH
,
8A43
,
6XRE
,
7LBM
,
6DRD
,
5IYD
,
5IYC
,
8ITY
,
7DN3
,
7D58
,
6O9L
,
7OB9
,
7AEA
,
7D59
,
7AST
,
8IUE
,
7OBB
,
5IY6
,
7OBA
,
5IY9
,
7VBA
,
5IYA
,
5IYB
,
5IY7
,
7VBC
,
7VBB
,
5IY8
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.867
9
UniProt:O15514 POLR2D
1
POLR2D [nucleoplasm]
(R-HSA-63508)
0.738
5
UniProt:Q9BWH6 RPAP1
0.666
5
UniProt:P60900 PSMA6
2
PSMA6 [cytosol]
(R-HSA-68734)
PSMA6 [nucleoplasm]
(R-HSA-174314)
0.556
3
UniProt:Q15645 PCH2
0.556
3
UniProt:Q8IXK0 PHC2
1
PHC2 [nucleoplasm]
(R-HSA-389112)
0.556
3
UniProt:Q96RE7 NACC1
0.556
3
UniProt:O43829 ZBT14
0.556
3
UniProt:Q9NVV9 THAP1
0.556
3
UniProt:O95994 AGR2
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q9NTX9 F217B
0.556
3
UniProt:Q96JM7 LMBL3
0.556
3
UniProt:Q96R06 SPAG5
0.556
3
UniProt:Q13625-3 TP53BP2
0.556
3
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:P38432 COIL
0.556
3
UniProt:P52434 POLR2H
2
POLR2H [cytosol]
(R-HSA-1964450)
POLR2H [nucleoplasm]
(R-HSA-63523)
0.527
2
UniProt:A6NED2 RCCD1
2
3OHR141-RCCD1 [cytosol]
(R-HSA-9629871)
RCCD1 [cytosol]
(R-HSA-9629873)
0.527
3
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.527
2
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.527
3
UniProt:O95602 POLR1A
1
POLR1A [nucleoplasm]
(R-HSA-63494)
0.527
3
UniProt:Q9H9Y6 POLR1B
1
POLR1B [nucleoplasm]
(R-HSA-63496)
0.527
3
UniProt:O15160 POLR1C
2
POLR1C [cytosol]
(R-HSA-1964454)
POLR1C [nucleoplasm]
(R-HSA-63498)
0.527
3
UniProt:P61218 POLR2F
2
POLR2F [cytosol]
(R-HSA-1964441)
POLR2F [nucleoplasm]
(R-HSA-83714)
0.527
4
UniProt:Q9H1D9 POLR3F
2
POLR3F [cytosol]
(R-HSA-1964434)
POLR3F [nucleoplasm]
(R-HSA-83708)
0.527
3
UniProt:P0DPB6 RPAC2
0.527
2
UniProt:A0JLT2 MED19
1
MED19 [nucleoplasm]
(R-HSA-556819)
0.527
2
UniProt:O14802 POLR3A
2
POLR3A [cytosol]
(R-HSA-1964433)
POLR3A [nucleoplasm]
(R-HSA-83700)
0.527
3
UniProt:Q9Y535 POLR3H
2
POLR3H [cytosol]
(R-HSA-1964440)
POLR3H [nucleoplasm]
(R-HSA-83710)
0.527
3
UniProt:Q9GZS1 POLR1E
1
POLR1E [nucleoplasm]
(R-HSA-5419294)
0.527
3
UniProt:Q9H9Y4 GPN2
0.527
3
UniProt:P05423 POLR3D
2
POLR3D [nucleoplasm]
(R-HSA-83704)
POLR3D [cytosol]
(R-HSA-1964429)
0.527
3
UniProt:Q9NVU0 POLR3E
2
POLR3E [cytosol]
(R-HSA-1964451)
POLR3E [nucleoplasm]
(R-HSA-83706)
0.527
3
UniProt:P19387 POLR2C
1
POLR2C [nucleoplasm]
(R-HSA-63506)
0.527
3
UniProt:P52435 POLR2J
1
POLR2J [nucleoplasm]
(R-HSA-63531)
0.527
4
UniProt:Q9BT43 POLR3GL
2
POLR3GL [nucleoplasm]
(R-HSA-1964458)
POLR3GL [cytosol]
(R-HSA-1964463)
0.527
3
UniProt:P30876 POLR2B
1
POLR2B [nucleoplasm]
(R-HSA-63504)
0.527
3
UniProt:Q9NWS0 PIHD1
0.527
2
UniProt:Q96P16 RPRD1A
1
RPRD1A [nucleoplasm]
(R-HSA-6814899)
0.527
3
UniProt:Q9NQG5 RPRD1B
1
RPRD1B [nucleoplasm]
(R-HSA-6814894)
0.527
3
UniProt:Q9NW08 POLR3B
2
POLR3B [cytosol]
(R-HSA-1964435)
POLR3B [nucleoplasm]
(R-HSA-83702)
0.527
3
UniProt:P62487 POLR2G
1
POLR2G [nucleoplasm]
(R-HSA-63517)
0.527
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text