Reactome | POLR2F [nucleoplasm]

POLR2F [nucleoplasm]

Stable Identifier

R-HSA-83714

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HsRPABC2, DNA-directed RNA polymerase II 14.4 kDa polypeptide (EC 2.7.7.6) (RPB6) (RPB14.4), DNA-directed RNA polymerase II 14.4 kDa polypeptide , RPB6, RPB14.4, RPABC2

Locations in the PathwayBrowser for interactor UniProt:O95602 POLR1A

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External Reference Information

External Reference

UniProt:P61218 POLR2F

Gene Names

POLR2F, POLRF

Chain

initiator methionine:, chain:2-127

Reference Genes

BioGPS Gene:5435 POLR2F

COSMIC (genes):POLR2F POLR2F

CTD Gene:5435 POLR2F

dbSNP Gene:5435 POLR2F

ENSEMBL:ENSG00000100142 POLR2F

ENSEMBL_homo_sapiens_GENE:ENSG00000100142.16 POLR2F

HGNC:9193 POLR2F

KEGG Gene (Homo sapiens):5435 POLR2F

Monarch:5435 POLR2F

NCBI Gene:5435 POLR2F

OMIM:604414 POLR2F

UCSC:P61218 POLR2F

Reference Transcript

RefSeq:NM_021974.4 POLR2F

Other Identifiers

11720324_a_at

11720325_at

209511_PM_at

209511_at

36027_at

3945134

3945136

3945138

3945141

3945143

3945144

3945145

5435

8072979

A_24_P417007

A_33_P3318960

GO:0000428

GO:0001054

GO:0001055

GO:0001056

GO:0001650

GO:0003677

GO:0003824

GO:0003899

GO:0005634

GO:0005654

GO:0005665

GO:0005666

GO:0005730

GO:0005736

GO:0005829

GO:0006351

GO:0006360

GO:0006366

GO:0006399

GO:0016740

GO:0042797

GO:0043226

GO:0140098

HMNXSV003017910

PH_hs_0003285

Z27113_at

g13097770_3p_at

g13097770_3p_x_at

Participates

as a component of

as an input of

Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)

Other forms of this molecule

POLR2F [cytosol]

Inferred To

polr2f [nucleoplasm] (Danio rerio)

polr2f [nucleoplasm] (Dictyostelium discoideum)

polr2f [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of POLR2F [nucleoplasm] (Canis familiaris)

RPO26 [nucleoplasm] (Saccharomyces cerevisiae)

Polr2F [nucleoplasm] (Drosophila melanogaster)

rpb6 [nucleoplasm] (Schizosaccharomyces pombe)

rpb-6 [nucleoplasm] (Caenorhabditis elegans)

RPB6 [nucleoplasm] (Gallus gallus)

POLR2F [nucleoplasm] (Bos taurus)

POLR2F [nucleoplasm] (Plasmodium falciparum)

POLR2F [nucleoplasm] (Sus scrofa)

Polr2f [nucleoplasm] (Mus musculus)

Polr2f [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_068809.1

OpenTargets

ENSG00000100142

GeneCards

P61218

HPA

ENSG00000100142-POLR2F

Ensembl

ENSP00000403852, ENSG00000100142, ENST00000442738

PRO

P61218

Pharos - Targets

P61218

HMDB Protein

HMDBP11912

PDB

7DU2, 8IUH, 5IYA, 7VBB, 7VBC, 7AEA, 7DTI, 7DTH, 6XRE, 5IY9, 5IY8, 7AE3, 6O9L, 8A43, 7OB9, 5IY7, 7LBM, 7A6H, 7AE1, 5IY6, 7DN3, 7OBA, 8ITY, 7D59, 6DRD, 7FJJ, 5IYC, 7OBB, 7D58, 5IYD, 7AST, 7VBA, 7FJI, 5IYB, 8IUE, 1QKL

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.867	11
UniProt:P62487 POLR2G	1	POLR2G [nucleoplasm] (R-HSA-63517)	0.643	5
UniProt:Q9NW08 POLR3B	2	POLR3B [cytosol] (R-HSA-1964435) POLR3B [nucleoplasm] (R-HSA-83702)	0.643	6
UniProt:P24928 POLR2A	7	p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) POLR2A [nucleoplasm] (R-HSA-63502)	0.643	5
UniProt:P36954 POLR2I	1	POLR2I [nucleoplasm] (R-HSA-63525)	0.643	5
UniProt:Q9BT43 POLR3GL	2	POLR3GL [nucleoplasm] (R-HSA-1964458) POLR3GL [cytosol] (R-HSA-1964463)	0.643	5
UniProt:O75575 CRCP	2	CRCP [nucleoplasm] (R-HSA-5420844) CRCP [cytosol] (R-HSA-5420849)	0.643	5
UniProt:P52435 POLR2J	1	POLR2J [nucleoplasm] (R-HSA-63531)	0.643	6
UniProt:O95602 POLR1A	1	POLR1A [nucleoplasm] (R-HSA-63494)	0.643	6
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.643	5
UniProt:Q9NVU0 POLR3E	2	POLR3E [nucleoplasm] (R-HSA-83706) POLR3E [cytosol] (R-HSA-1964451)	0.643	6
UniProt:O15446 POLR1G	1	CD3EAP [nucleoplasm] (R-HSA-5419289)	0.643	5
UniProt:P05423 POLR3D	2	POLR3D [nucleoplasm] (R-HSA-83704) POLR3D [cytosol] (R-HSA-1964429)	0.643	5
UniProt:Q9Y2Y1 POLR3K	2	POLR3K [nucleoplasm] (R-HSA-1964461) POLR3K [cytosol] (R-HSA-1964455)	0.643	5
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.643	6
UniProt:Q9Y535 POLR3H	2	POLR3H [nucleoplasm] (R-HSA-83710) POLR3H [cytosol] (R-HSA-1964440)	0.643	5
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.643	5
UniProt:O14802 POLR3A	2	POLR3A [cytosol] (R-HSA-1964433) POLR3A [nucleoplasm] (R-HSA-83700)	0.643	5
UniProt:Q9BUI4 POLR3C	2	POLR3C [cytosol] (R-HSA-1964448) POLR3C [nucleoplasm] (R-HSA-1964430)	0.643	5
UniProt:P0DPB6 RPAC2			0.643	4
UniProt:Q9H1D9 POLR3F	2	POLR3F [cytosol] (R-HSA-1964434) POLR3F [nucleoplasm] (R-HSA-83708)	0.643	6
UniProt:Q9H9Y6 POLR1B	1	POLR1B [nucleoplasm] (R-HSA-63496)	0.643	5
UniProt:Q8WV16 DCAF4	1	DCAF4 [nucleoplasm] (R-HSA-8955191)	0.527	3
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.527	2
UniProt:P35269 GTF2F1	1	GTF2F1 [nucleoplasm] (R-HSA-65565)	0.527	2
UniProt:Q9NQG5 RPRD1B	1	RPRD1B [nucleoplasm] (R-HSA-6814894)	0.527	4
UniProt:Q9UHW5 GPN3			0.527	2
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.527	4
UniProt:Q7KZ85 SUPT6H	1	SUPT6H [nucleoplasm] (R-HSA-8932908)	0.527	3
UniProt:P52434 POLR2H	2	POLR2H [nucleoplasm] (R-HSA-63523) POLR2H [cytosol] (R-HSA-1964450)	0.527	4
UniProt:P62875 POLR2L	2	POLR2L [nucleoplasm] (R-HSA-83715) POLR2L [cytosol] (R-HSA-1964467)	0.527	4
UniProt:Q9Y5B0 CTDP1	1	CTDP1 [nucleoplasm] (R-HSA-113416)	0.527	2
UniProt:Q9GZS1 POLR1E	1	POLR1E [nucleoplasm] (R-HSA-5419294)	0.527	5
UniProt:Q8N7H5 PAF1	1	PAF1 [nucleoplasm] (R-HSA-8866689)	0.527	2
UniProt:O94762 RECQ5			0.527	4
UniProt:Q8IXW5 RPAP2	1	RPAP2 [nucleoplasm] (R-HSA-6810227)	0.527	4
UniProt:Q9HCN4 GPN1			0.527	4
UniProt:O15318 POLR3G	2	POLR3G [nucleoplasm] (R-HSA-1964459) POLR3G [cytosol] (R-HSA-1964446)	0.527	4
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.527	2
UniProt:Q9P1U0 POLR1H	1	ZNRD1 [nucleoplasm] (R-HSA-5419292)	0.527	2
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.527	2
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	3

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