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Binding of A1CF to stem-looped RNA
Stable Identifier
R-HSA-77608
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of RNA (Homo sapiens)
mRNA Editing (Homo sapiens)
mRNA Editing: C to U Conversion (Homo sapiens)
Formation of the Editosome (Homo sapiens)
Binding of A1CF to stem-looped RNA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
A1CF protein is cytosolic in origin and is translocated to nucleus where it binds to the target RNA. The order of events in the formation of editosomes, namely, binding of A1CF and APOBEC-1 are not well elucidated in human cells (Maris et al.2005).
Literature References
PubMed ID
Title
Journal
Year
15659357
NMR structure of the apoB mRNA stem-loop and its interaction with the C to U editing APOBEC1 complementary factor
Chester, A
,
Masse, J
,
Allain, FH
,
Navaratnam, N
,
Maris, C
RNA
2005
Participants
Input
A1CF [nucleoplasm]
(Homo sapiens)
Stem-looped mRNA [nucleoplasm]
Output
Stem-looped mRNA:ACF complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Formation of the Editosome (Homo sapiens)
Orthologous Events
Binding of A1CF to stem-looped RNA (Bos taurus)
Binding of A1CF to stem-looped RNA (Canis familiaris)
Binding of A1CF to stem-looped RNA (Gallus gallus)
Binding of A1CF to stem-looped RNA (Mus musculus)
Binding of A1CF to stem-looped RNA (Rattus norvegicus)
Binding of A1CF to stem-looped RNA (Sus scrofa)
Binding of A1CF to stem-looped RNA (Xenopus tropicalis)
Authored
Gopinathrao, G (2003-12-05)
Created
Carmichael, GG (2003-12-05)
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