Reactome | Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC

Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC

Stable Identifier

R-HSA-77594

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm, nuclear envelope

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Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC

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The polyadenylated, capped transcript and TAP dock at the nucleoplasmic side of the NPC. The Cap Binding Complex (CBC) and CPSF complexes are released back into the nucleoplasm (Zhou et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
15120988	Nuclear export of mRNA: from the site of transcription to the cytoplasm Erkmann, JA, Kutay, U	Exp. Cell Res.	2004
11014198	The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans Reed, R, Luo, MJ, Katahira, J, Hurt, E, Straesser, K, Zhou, Z	Nature	2000