Beta oxidation of octanoyl-CoA to hexanoyl-CoA

Stable Identifier
R-HSA-77348
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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Beta oxidation of octanoyl-CoA to hexanoyl-CoA
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The fifth pass through the beta-oxidation spiral picks up where the last left off with the saturated fatty acid octanoyl-CoA and produces hexanoyl-CoA. Four enzymatic steps are required starting with MCAD CoA dehydrogenase (Medium Chain) activity, followed by the enoyl-CoA hydratase activity of crotonase, the 3-hydroxyacyl-CoA dehydrogenase activity of the short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), and completed by the ketoacyl-CoA thiolase activity, present in the mitochondrial membrane associated trifunctional protein.
Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Beaudet, AL, Scriver, CR, Sly, WS, Valle, D

  2001
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
fatty acid beta-oxidation (0006635)
Orthologous Events
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Bos taurus)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Caenorhabditis elegans)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Canis familiaris)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Danio rerio)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Dictyostelium discoideum)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Drosophila melanogaster)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Gallus gallus)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Mus musculus)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Rattus norvegicus)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Sus scrofa)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (Xenopus tropicalis)
Authored
Gillespie, ME  (2003-09-19)
Created
Gillespie, ME  (2003-09-19)
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