Stable Identifier
Reaction [transition]
Homo sapiens
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At the beginning of this reaction, 1 molecule of 'NAD+', and 1 molecule of '(S)-3-Hydroxybutanoyl-CoA' are present. At the end of this reaction, 1 molecule of 'acetoacetyl-CoA', 1 molecule of 'H+', and 1 molecule of 'NADH' are present.

This reaction takes place in the 'mitochondrial matrix' and is mediated by the '3-hydroxyacyl-CoA dehydrogenase activity' of 'short chain 3-hydroxyacyl-CoA dehydrogenase homodimer'.

Literature References
PubMed ID Title Journal Year
10231530 Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism.

Barycki, JJ, O'Brien, LK, Banaszak, LJ, Sanishvili, R, Strauss, AW, Bratt, JM, Zhang, R

Biochemistry 1999
8687463 Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.

Berger, R, Malingré, HE, van den Berg, IE, Olde Weghuis, DE, Vredendaal, PJ, Stroobants, AK

Biochem Biophys Res Commun 1996
Catalyst Activity

3-hydroxyacyl-CoA dehydrogenase activity of HADH dimer [mitochondrial matrix]

Orthologous Events
Cross References
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