(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H

Stable Identifier
R-HSA-77312
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'NAD+', and 1 molecule of '(S)-3-Hydroxybutanoyl-CoA' are present. At the end of this reaction, 1 molecule of 'acetoacetyl-CoA', 1 molecule of 'H+', and 1 molecule of 'NADH' are present.

This reaction takes place in the 'mitochondrial matrix' and is mediated by the '3-hydroxyacyl-CoA dehydrogenase activity' of 'short chain 3-hydroxyacyl-CoA dehydrogenase homodimer'.

Literature References
PubMed ID Title Journal Year
10231530 Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism.

Barycki, JJ, O'Brien, LK, Banaszak, LJ, Sanishvili, R, Strauss, AW, Bratt, JM, Zhang, R

Biochemistry 1999
8687463 Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.

Berger, R, Malingré, HE, van den Berg, IE, Olde Weghuis, DE, Vredendaal, PJ, Stroobants, AK

Biochem Biophys Res Commun 1996
Participants
Participates
Catalyst Activity

3-hydroxyacyl-CoA dehydrogenase activity of HADH dimer [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Created
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