(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H

Stable Identifier
R-HSA-77312
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'NAD+', and 1 molecule of '(S)-3-Hydroxybutanoyl-CoA' are present. At the end of this reaction, 1 molecule of 'acetoacetyl-CoA', 1 molecule of 'H+', and 1 molecule of 'NADH' are present.

This reaction takes place in the 'mitochondrial matrix' and is mediated by the '3-hydroxyacyl-CoA dehydrogenase activity' of 'short chain 3-hydroxyacyl-CoA dehydrogenase homodimer'.
Literature References
PubMed ID Title Journal Year
10231530 Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism.

Barycki, JJ, O'Brien, LK, Banaszak, LJ, Sanishvili, R, Strauss, AW, Bratt, JM, Zhang, R

Biochemistry 1999
8687463 Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.

Berger, R, Malingré, HE, van den Berg, IE, Olde Weghuis, DE, Vredendaal, PJ, Stroobants, AK

Biochem Biophys Res Commun 1996
Participants
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Output
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as an event of
Catalyst Activity

3-hydroxyacyl-CoA dehydrogenase activity of HADH dimer [mitochondrial matrix]

Physical Entity
HADH dimer [mitochondrial matrix] (Homo sapiens)
Activity
3-hydroxyacyl-CoA dehydrogenase activity (GO:0003857)
Orthologous Events
(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Bos taurus)
(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Caenorhabditis elegans)
(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Canis familiaris)
(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Danio rerio)
(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Gallus gallus)
(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Mus musculus)
(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Rattus norvegicus)
(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Sus scrofa)
(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H (Xenopus tropicalis)
Cross References
Rhea
Created
Gillespie, ME  (2003-09-19)
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