Methylation of GMP-cap by RNA Methyltransferase

Stable Identifier
R-HSA-77090
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Methylation of GMP-cap by RNA Methyltransferase
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the final step of the capping reaction, the methyltransferase takes a methyl group from S-adenosyl-methionine to the N7 position of the cap guanine. N7G-methyltransferase (MT) mediated reaction can be represented as:
GpppN(pN)n + S-adenosylmethionine (Adomet) ->m7GpppN(pN)n + S-adenosylhomocysteine (Adohcy).

Literature References
PubMed ID Title Journal Year
9790902 Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.

Shibagaki, Y, Niikura, Y, Tsukamoto, T, Mizumoto, K

Biochem Biophys Res Commun 1998
Participants
Input
Output
Participates
as an event of
Catalyst Activity

mRNA 5'-cap (guanine-N7-)-methyltransferase activity of Capping complex (with freed 5'- GMP) [nucleoplasm]

Physical Entity
Capping complex (with freed 5'- GMP) [nucleoplasm] (Homo sapiens)
Activity
mRNA 5'-cap (guanine-N7-)-methyltransferase activity (GO:0004482)
Orthologous Events
Methylation of GMP-cap by RNA Methyltransferase (Bos taurus)
Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)
Methylation of GMP-cap by RNA Methyltransferase (Canis familiaris)
Methylation of GMP-cap by RNA Methyltransferase (Dictyostelium discoideum)
Methylation of GMP-cap by RNA Methyltransferase (Drosophila melanogaster)
Methylation of GMP-cap by RNA Methyltransferase (Mus musculus)
Methylation of GMP-cap by RNA Methyltransferase (Rattus norvegicus)
Methylation of GMP-cap by RNA Methyltransferase (Saccharomyces cerevisiae)
Methylation of GMP-cap by RNA Methyltransferase (Schizosaccharomyces pombe)
Methylation of GMP-cap by RNA Methyltransferase (Sus scrofa)
Authored
Buratowski, S  (2003-10-15)
Created
Buratowski, S  (2003-10-15)
Cite Us!