CYP4A11 12-hydroxylates DDCX

Stable Identifier
R-HSA-76466
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
dodecanoic acid + O2 + NADPH + H+ -> 12-hydroxydodecanoic acid + H2O + NADP+
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Dodecanoic acid (DDCX aka lauric acid) is a medium-chain fatty acid which serves as a model substrate for studying the CYP4A gene subfamily of cytochrome P450s. CYP4A11 and CYP2E1 are the principal isozymes involved in omega-hydroxylation and omega-1 hydroxylation respectively of DDCX.

Literature References
PubMed ID Title Journal Year
8914854 Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes

Powell, PK, Wolf, I, Lasker, JM

Arch Biochem Biophys 1996
Participants
Participant Of
hasEvent
Event Information
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP4A11 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created