CYP4A11 12-hydroxylates DDCX

Stable Identifier
R-HSA-76466
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
Synonyms
dodecanoic acid + O2 + NADPH + H+ -> 12-hydroxydodecanoic acid + H2O + NADP+
ReviewStatus
5/5
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CYP4A11 12-hydroxylates DDCX
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Dodecanoic acid (DDCX aka lauric acid) is a medium-chain fatty acid which serves as a model substrate for studying the CYP4A gene subfamily of cytochrome P450s. CYP4A11 and CYP2E1 are the principal isozymes involved in omega-hydroxylation and omega-1 hydroxylation respectively of DDCX.
Literature References
PubMed ID Title Journal Year
8914854 Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes

Powell, PK, Wolf, I, Lasker, JM

Arch Biochem Biophys 1996
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
fatty acid metabolic process (0006631)
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP4A11 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP4A11 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
CYP4A11 12-hydroxylates DDCX (Bos taurus)
CYP4A11 12-hydroxylates DDCX (Canis familiaris)
CYP4A11 12-hydroxylates DDCX (Gallus gallus)
CYP4A11 12-hydroxylates DDCX (Mus musculus)
CYP4A11 12-hydroxylates DDCX (Rattus norvegicus)
CYP4A11 12-hydroxylates DDCX (Sus scrofa)
CYP4A11 12-hydroxylates DDCX (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2003-08-05)
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