Reactome | N-hydroxylation of 4-aminobiphenyl

N-hydroxylation of 4-aminobiphenyl

Stable Identifier

R-HSA-76373

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Xenobiotics (Homo sapiens)
        
        Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (Homo sapiens)
        
        N-hydroxylation of 4-aminobiphenyl (Homo sapiens)

General

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Heterocyclic and aromatic amines require metabolic activation to convert them to genotoxic metabolites.The initial step is N-hydroxylation and cytochrome P450 1A2 can carry out the catalysis.

Literature References

PubMed ID	Title	Journal	Year
1934265	Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon Teitel, CH, Turesky, RJ, Butler, MA, Lang, NP, Kadlubar, FF	Carcinogenesis	1991
9111224	Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes Tukey, RH, Guengerich, FP, Milton, D, Hammons, GJ, Kadlubar, FF, Stepps, K	Carcinogenesis	1997