N-hydroxylation of 4-aminobiphenyl

Stable Identifier
R-HSA-76373
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
ReviewStatus
5/5
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N-hydroxylation of 4-aminobiphenyl
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Heterocyclic and aromatic amines require metabolic activation to convert them to genotoxic metabolites.The initial step is N-hydroxylation and cytochrome P450 1A2 can carry out the catalysis.
Literature References
PubMed ID Title Journal Year
1934265 Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

Teitel, CH, Turesky, RJ, Butler, MA, Lang, NP, Kadlubar, FF

Carcinogenesis 1991
9111224 Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes

Tukey, RH, Guengerich, FP, Milton, D, Hammons, GJ, Kadlubar, FF, Stepps, K

Carcinogenesis 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]

Physical Entity
CYP1A2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
N-hydroxylation of 4-aminobiphenyl (Bos taurus)
N-hydroxylation of 4-aminobiphenyl (Danio rerio)
N-hydroxylation of 4-aminobiphenyl (Gallus gallus)
N-hydroxylation of 4-aminobiphenyl (Mus musculus)
N-hydroxylation of 4-aminobiphenyl (Rattus norvegicus)
N-hydroxylation of 4-aminobiphenyl (Sus scrofa)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2003-08-05)
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