CYP2E1 can catalyze the oxidation of the vinyl halide vinyl chloride to the epoxide 2-chloroethylene oxide. The epoxide is very unstable and rearranges quickly to 2-chloroacetaldehyde. Both these products can interact with DNA and proteins.
Guengerich, FP, Crawford, WM Jr, Watanabe, PG
Guengerich, FP, Kim, DH, Iwasaki, M
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