Vinyl chloride is oxidized to 2-Chloroethylene oxide

Stable Identifier
R-HSA-76354
Type
Reaction
Species
Homo sapiens
Compartment
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CYP2E1 can catalyze the oxidation of the vinyl halide vinyl chloride to the epoxide 2-chloroethylene oxide. The epoxide is very unstable and rearranges quickly to 2-chloroacetaldehyde. Both these products can interact with DNA and proteins.

Literature References
PubMed ID Title Journal Year
1664256 Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

Kim, DH, Iwasaki, M, Guengerich, FP

Chem Res Toxicol 1991
497175 Activation of vinyl chloride to covalently bound metabolites: roles of 2-chloroethylene oxide and 2-chloroacetaldehyde

Watanabe, PG, Guengerich, FP, Crawford, WM Jr

Biochemistry 1979
Participants
Participates
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]

Orthologous Events
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