2 H2O2 => O2 + 2 H2O

Stable Identifier
R-HSA-76031
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
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2 H2O2 => O2 + 2 H2O
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Hydrogen peroxide is generated in the course of peroxisomal fatty acid oxidation and purine catabolism, and is rapidly converted to water and molecular oxygen by the enzyme catalase. This enzyme is widely distributed in the body, but is especially abundant in liver, kidney, and red blood cells.

Literature References
PubMed ID Title Journal Year
1999334 Acatalasemia.

Ogata, M

Hum Genet 1991
10656833 Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.

Putnam, CD, Arvai, AS, Bourne, Y, Tainer, JA

J Mol Biol 2000
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
catalase activity of CAT tetramer [peroxisomal matrix]
Physical Entity
CAT tetramer [peroxisomal matrix]
Activity
catalase activity (0004096)
Orthologous Events
2 H2O2 => O2 + 2 H2O (Bos taurus)
2 H2O2 => O2 + 2 H2O (Caenorhabditis elegans)
2 H2O2 => O2 + 2 H2O (Canis familiaris)
2 H2O2 => O2 + 2 H2O (Danio rerio)
2 H2O2 => O2 + 2 H2O (Dictyostelium discoideum)
2 H2O2 => O2 + 2 H2O (Drosophila melanogaster)
2 H2O2 => O2 + 2 H2O (Gallus gallus)
2 H2O2 => O2 + 2 H2O (Mus musculus)
2 H2O2 => O2 + 2 H2O (Rattus norvegicus)
2 H2O2 => O2 + 2 H2O (Saccharomyces cerevisiae)
2 H2O2 => O2 + 2 H2O (Schizosaccharomyces pombe)
2 H2O2 => O2 + 2 H2O (Xenopus tropicalis)
Authored
D'Eustachio, P  (2003-09-15)
Created
D'Eustachio, P  (2003-09-15)