Dihydroxyacetone phosphate (DHAP) is converted to glycerol-3-phosphate (G3P) by glycerol-3-phosphate dehydrogenase (GPD1) or by glycerol-3-phosphate dehydrogenase-like (GPD1L) enzymes (Ou et al. 2006, Valdivia et al. 2009). The active forms of both enzymes are homodimers. This reaction may be found in white adipose tissues where glycerol-3-kinase activity is not observed in sufficient levels. GPD1/GPD1L reduces dihydroxyacetone phosphate with NADH donating electrons to this reduction.
Valdivia, CR, Ueda, K, Ackerman, MJ, Makielski, JC
Ou, X, Ji, C, Han, X, Zhao, X, Li, X, Mao, Y, Wong, LL, Bartlam, M, Rao, Z
© 2021 Reactome
