DHRS7B reduces GO3P to HXDG3P

Stable Identifier
R-HSA-75883
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+, Conversion of acylated DHAP to lysophosphatidic acid
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DHRS7B (Dehydrogenase/reductase SDR family member 7B) catalyzes the reaction of NADPH and GO3P (O-hexadecyldihydroxyacetone phosphate) to form HXDG3P (1-hexadecyl glycerol-3-phosphate) and NADP+. The enzyme is associated with the outer face of the peroxisomal membrane; its substrates and products are thought to be cytosolic. The properties of the human enzyme are inferred from those of an activity purified from guinea pig liver (Datta et al. 1990). More recent studies of HXDG3P metabolism in cultured human cells in which DHRS7B activity was knocked down confirm the specificity of the human enzyme (Lodhi et al. 2012).

Literature References
PubMed ID Title Journal Year
22863804 Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARĪ³ activation to decrease diet-induced obesity

Lodhi, IJ, Yin, L, Jensen-Urstad, AP, Funai, K, Coleman, T, Baird, JH, El Ramahi, MK, Razani, B, Song, H, Fu-Hsu, F, Turk, J, Semenkovich, CF

Cell Metab. 2012
2335525 Purification and properties of acyl/alkyl dihydroxyacetone-phosphate reductase from guinea pig liver peroxisomes

Datta, SC, Ghosh, MK, Hajra, AK

J Biol Chem 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acylglycerone-phosphate reductase activity of DHRS7B [peroxisomal membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created