TRAIL binds TRAIL receptors

Stable Identifier
R-HSA-75238
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Synonyms
TNFSF10 binds TNFRSF10A or TNFRSF10B, TRAIL Binds TRAIL Receptor-1 or TRAIL Receptor-2, TRAIL binds DR4 or DR5
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TRAIL binds TRAIL receptors
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TRAIL (TNF-related apoptosis-inducing ligand) binds TRAIL receptor-1 (TNFRSF10A) or TRAIL receptor-2 (TNFRSF10B) (Wiley et al. 1995, Pan et al. 1997, Walczak et al. 1997).

Literature References
PubMed ID Title Journal Year
9311998 TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL

Walczak, H, Degli-Esposti, MA, Johnson, RS, Smolak, PJ, Waugh, JY, Boiani, N, Timour, MS, Gerhart, MJ, Schooley, KA, Smith, CA, Goodwin, RG, Rauch, CT

EMBO J. 1997
8777713 Identification and characterization of a new member of the TNF family that induces apoptosis

Wiley, SR, Schooley, K, Smolak, PJ, Din, WS, Huang, CP, Nicholl, JK, Sutherland, GR, Smith, TD, Rauch, C, Smith, CA

Immunity 1995
9082980 The receptor for the cytotoxic ligand TRAIL

Pan, G, O'Rourke, K, Chinnaiyan, AM, Gentz, R, Ebner, R, Ni, J, Dixit, VM

Science 1997
Participants
Input
Output
Participant Of
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Orthologous Events
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TRAIL binds TRAIL receptors (Danio rerio)
TRAIL binds TRAIL receptors (Gallus gallus)
TRAIL binds TRAIL receptors (Mus musculus)
TRAIL binds TRAIL receptors (Sus scrofa)
TRAIL binds TRAIL receptors (Xenopus tropicalis)
Reviewed
Pop, C  (2013-05-22)
Salvesen, GS  (2013-05-22)
Created
Tschopp, J  (2004-01-28)