Reactome | TRAIL:TRAIL receptor trimers bind FADD

TRAIL:TRAIL receptor trimers bind FADD

Stable Identifier

R-HSA-75187

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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The trimeric complex of TRAIL and TRAIL receptor-1 (TNFSF10:TNFRSF10A) or TRAIL receptor-2 (TNFSF10:TNFRSF10B) binds FADD (Sprick et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
17327223	Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis Kohlhaas, SL, Craxton, A, Sun, XM, Pinkoski, MJ, Cohen, GM	J. Biol. Chem.	2007
10894160	FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2 Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H	Immunity	2000