TRAIL:TRAIL receptor trimers bind FADD

Stable Identifier
R-HSA-75187
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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TRAIL:TRAIL receptor trimers bind FADD
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The trimeric complex of TRAIL and TRAIL receptor-1 (TNFSF10:TNFRSF10A) or TRAIL receptor-2 (TNFSF10:TNFRSF10B) binds FADD (Sprick et al. 2000).

Literature References
PubMed ID Title Journal Year
10894160 FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H

Immunity 2000
17327223 Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis

Kohlhaas, SL, Craxton, A, Sun, XM, Pinkoski, MJ, Cohen, GM

J. Biol. Chem. 2007
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Negatively by
Orthologous Events
TRAIL:TRAIL receptor trimers bind FADD (Bos taurus)
TRAIL:TRAIL receptor trimers bind FADD (Danio rerio)
TRAIL:TRAIL receptor trimers bind FADD (Gallus gallus)
TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)
TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)
TRAIL:TRAIL receptor trimers bind FADD (Sus scrofa)
TRAIL:TRAIL receptor trimers bind FADD (Xenopus tropicalis)
Reviewed
Pop, C  (2013-05-22)
Salvesen, GS  (2013-05-22)
Created
Tschopp, J  (2004-01-28)