TRAIL:TRAIL receptor trimers bind FADD

Stable Identifier
R-HSA-75187
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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TRAIL:TRAIL receptor trimers bind FADD
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The trimeric complex of TRAIL and TRAIL receptor-1 (TNFSF10:TNFRSF10A) or TRAIL receptor-2 (TNFSF10:TNFRSF10B) binds FADD (Sprick et al. 2000).

Literature References
PubMed ID Title Journal Year
17327223 Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis

Cohen, GM, Pinkoski, MJ, Kohlhaas, SL, Sun, XM, Craxton, A

J. Biol. Chem. 2007
10894160 FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Juo, P, Blenis, J, Weigand, MA, Sprick, MR, Rauch, CT, Rieser, E, Walczak, H, Krammer, PH

Immunity 2000
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CFLAR(1-376) [cytosol] (Homo sapiens)
Orthologous Events
TRAIL:TRAIL receptor trimers bind FADD (Danio rerio)
TRAIL:TRAIL receptor trimers bind FADD (Gallus gallus)
TRAIL:TRAIL receptor trimers bind FADD (Mus musculus)
TRAIL:TRAIL receptor trimers bind FADD (Rattus norvegicus)
TRAIL:TRAIL receptor trimers bind FADD (Xenopus tropicalis)
Reviewed
Salvesen, GS  (2013-05-22)
Pop, C  (2013-05-22)
Created
Tschopp, J  (2004-01-28)
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