TRAIL:TRAIL receptor trimers bind FADD

Stable Identifier
R-HSA-75187
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The trimeric complex of TRAIL and TRAIL receptor-1 (TNFSF10:TNFRSF10A) or TRAIL receptor-2 (TNFSF10:TNFRSF10B) binds FADD (Sprick et al. 2000).
Literature References
PubMed ID Title Journal Year
17327223 Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis

Cohen, GM, Pinkoski, MJ, Kohlhaas, SL, Sun, XM, Craxton, A

J. Biol. Chem. 2007
10894160 FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Juo, P, Blenis, J, Weigand, MA, Sprick, MR, Rauch, CT, Rieser, E, Walczak, H, Krammer, PH

Immunity 2000
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This event is regulated
Negatively by
Orthologous Events
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