FasL/ CD95L signaling

Stable Identifier
R-HSA-75157
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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FasL/ CD95L signaling
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The Fas family of cell surface receptors initiate the apototic pathway through interaction with the external ligand, FasL. The cytoplasmic domain of Fas interacts with a number of molecules in the transduction of the external signal to the cytoplasmic side of the cell membrane. The most notable cytoplasmic domain is the Death Domain (DD) that is involved in recruiting the FAS-associating death domain-containing protein (FADD). This interaction drives downstream events.
Literature References
PubMed ID Title Journal Year
11048727 The biochemistry of apoptosis.

Hengartner, MO

Nature 2000
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
apoptotic signaling pathway (0097190)
Orthologous Events
FasL/ CD95L signaling (Bos taurus)
FasL/ CD95L signaling (Canis familiaris)
FasL/ CD95L signaling (Gallus gallus)
FasL/ CD95L signaling (Mus musculus)
FasL/ CD95L signaling (Rattus norvegicus)
FasL/ CD95L signaling (Sus scrofa)
FasL/ CD95L signaling (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Gillespie, ME  (2004-08-19)
Reviewed
Salvesen, GS  (2013-05-22)
Pop, C  (2013-05-22)
Vaux, DL  (2024-05-24)
Created
Tschopp, J  (2004-01-28)
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