TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8

Stable Identifier
R-HSA-75146
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8
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FADD recruits caspase-8 precursor to trimeric complex of TRAIL (TNFSF10) and TRAIL receptors (TNFRSF10A or TNFRSF10B) (Sprick et al. 2000).
Literature References
PubMed ID Title Journal Year
10894160 FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Juo, P, Blenis, J, Weigand, MA, Sprick, MR, Rauch, CT, Rieser, E, Walczak, H, Krammer, PH

Immunity 2000
Participants
Input
Output
Participates
as an event of
Orthologous Events
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Gallus gallus)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Mus musculus)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)
Authored
Gillespie, ME  (2004-08-25)
Reviewed
Salvesen, GS  (2013-05-22)
Pop, C  (2013-05-22)
Created
Tschopp, J  (2004-01-28)
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