Reactome | TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8

TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8

Stable Identifier

R-HSA-75146

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8

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FADD recruits caspase-8 precursor to trimeric complex of TRAIL (TNFSF10) and TRAIL receptors (TNFRSF10A or TNFRSF10B) (Sprick et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10894160	FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2 Juo, P, Blenis, J, Weigand, MA, Sprick, MR, Rauch, CT, Rieser, E, Walczak, H, Krammer, PH	Immunity	2000