The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active alpha subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (s):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates into the inactive heterotrimeric G-protein.
Oldham, WM, Hamm, HE
Preininger, A, Mazzoni, MR, Medkova, M, Vanhauwe, J, Cabrera-Vera, TM, Hamm, HE, Thomas, TO
Siderovski, DP, Willard, FS
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