Transport of the export-competent mRNP complex through the NPC

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In this reaction, 1 molecule of 'Export Receptor bound mature mRNA Complex' is translocated from nucleoplasm to cytosol.

This reaction takes place in the 'nuclear envelope'.

Literature References
PubMed ID Title Journal Year
9618489 The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export

Watkins, JL, Wente, SR, Emtage, JL, Murphy, R

Proc. Natl. Acad. Sci. U.S.A. 1998
11259411 Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export

Herold, A, Braun, IC, Izaurralde, E, Rode, M, Conti, E

J. Biol. Chem. 2001
10323864 The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences

Cullen, BR, Kang, Y

Genes Dev. 1999
16314397 Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex

Berberoglu, S, Bor, YC, Rekosh, D, Lévesque, L, Paschal, BM, Jin, L, Matzat, LH, Hammarskjold, ML

Mol. Biol. Cell 2006
11579093 RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex

Guan, T, Paschal, BM, Coyle, J, Guzik, B, Black, BE, Lévesque, L, Hammarskjöld, ML, Rekosh, D

J. Biol. Chem. 2001
9660949 TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus

Izaurralde, E, Saavedra, C, Schmitt, C, Grüter, P, Wilm, M, Tabernero, C, Bachi, A, Felber, BK, von Kobbe, C

Mol. Cell 1998
11259602 NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells

Bor, YC, Guzik, BW, Paschal, BM, Levesque, L, Black, BE, Hammarskjöld, ML, Rekosh, D, Prasad, S

Mol. Cell. Biol. 2001
10228171 The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

Strässer, K, Podtelejnikov, A, Jung, JU, Katahira, J, Hurt, E, Mann, M

EMBO J. 1999
11739738 Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes

Coburn, GA, Wiegand, HL, Bogerd, HP, Zeng, Y, Kang, Y, Cullen, BR

Mol. Cell. Biol. 2002
Event Information
Go Biological Process
This event is regulated
Orthologous Events
Cite Us!