Formation of AT-AC B Complex

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The U4atac/U6atac enters the spliceosome and U6atac snRNA forms base pairing interactions with the 5' ss and also forms base pairing interactions with U12 and U4atac is partially displaced. U5 snRNP, the only snRNP common to both the major and minor splicing pathways, also joins the spliceosome to form the B complex and interacts with nucleotides within the 3' end of the exon flanking the 5' ss (Singh et al.2016, Wu and Krainer 1999).

Literature References
PubMed ID Title Journal Year
10207048 AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.

Krainer, AR, Wu, Q

Mol Cell Biol 1999
27510544 U6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III

Komar, AA, Will, CL, Conrad, H, Shukla, GC, Sikand, K, Singh, J

Sci Rep 2016
Orthologous Events
Cite Us!