Reactome | Association of p-S216-CDC25C with 14-3-3 proteins

Association of p-S216-CDC25C with 14-3-3 proteins

Stable Identifier

R-HSA-75016

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Association of p-S216-CDC25C with 14-3-3 proteins

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CDC25C is phosphorylated by CHK1 at ser-216 (Blasina et al.,1999 ) resulting in both inhibition of the CDC25 phosphatase activity and creation of a 14-3-3 docking site (Peng et al., 1997). Association of 14-3-3 proteins with phosphorylated CDC25C (p-S216-CDC25C) is thought to result in retention of this complex within the cytoplasm (Dalal et al., 1999; Graves et al, 2001).

Literature References

PubMed ID	Title	Journal	Year
10330186	Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site. Dalal, SN, Schweitzer, CM, Gan, J, DeCaprio, JA	Mol Cell Biol	1999
11313932	Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Graves, PR, Lovly, CM, Uy, GL, Piwnica-Worms, H	Oncogene	2001
9278512	Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Peng, CY, Graves, PR, Thoma, RS, Wu, Z, Shaw, AS, Piwnica-Worms, H	Science	1997
9889122	A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase Blasina, A, de Weyer, IV, Laus, MC, Luyten, WH, Parker, AE, McGowan, CH	Curr Biol	1999