CDC25C is phosphorylated by CHK1 at ser-216 (Blasina et al.,1999 ) resulting in both inhibition of the CDC25 phosphatase activity and creation of a 14-3-3 docking site (Peng et al., 1997). Association of 14-3-3 proteins with phosphorylated CDC25C (p-S216-CDC25C) is thought to result in retention of this complex within the cytoplasm (Dalal et al., 1999; Graves et al, 2001).
Graves, PR, Lovly, CM, Uy, GL, Piwnica-Worms, H
Dalal, SN, Schweitzer, CM, Gan, J, DeCaprio, JA
Peng, CY, Graves, PR, Thoma, RS, Wu, Z, Shaw, AS, Piwnica-Worms, H
Blasina, A, de Weyer, IV, Laus, MC, Luyten, WH, Parker, AE, McGowan, CH
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