PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box

Stable Identifier
R-HSA-74993
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Dissociation of paused ternary complexes requires the Polymerase I-transcript release factor (PTRF) a leucine zipper protein. PTRF is capable of dissociating ternary Pol I transcription complexes, interacting with both TTF-I and Pol I to mediate the release of both Pol I and nascent transcripts from the template.

Literature References
PubMed ID Title Journal Year
9582279 Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.

Jansa, P, Mason, SW, Hoffmann-Rohrer, U, Grummt, I

EMBO J 1998
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