Reactome | PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box

PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box

Stable Identifier

R-HSA-74993

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box

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Dissociation of paused ternary complexes requires the Polymerase I-transcript release factor (PTRF) a leucine zipper protein. PTRF is capable of dissociating ternary Pol I transcription complexes, interacting with both TTF-I and Pol I to mediate the release of both Pol I and nascent transcripts from the template.

Literature References

PubMed ID	Title	Journal	Year
9582279	Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. Grummt, I, Hoffmann-Rohrer, U, Mason, SW, Jansa, P	EMBO J	1998