p-MII:SAG dissociates to p-RHO and SAG

Stable Identifier
R-HSA-74947
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Loss of all-trans-retinal (atRAL) is followed by dissociation of arrestin (SAG) from p-RHO. RHO is then available for covalent binding to 11-cis-retinal (11cRAL), supplied by the retinal pigment epithelium, to regenerate rhodopsin. SAG is capable of binding weakly to rhodopsin, so the dissociation in some rhodopsins may occur after regeneration (Baumann & Bender 1973).

Literature References
PubMed ID Title Journal Year
4772407 Kinetics of rhodopsin bleaching in the isolated human retina

Baumann, C, Bender, S

J. Physiol. (Lond.) 1973
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