Reactome | p-MII:SAG dissociates to p-RHO and SAG

p-MII:SAG dissociates to p-RHO and SAG

Stable Identifier

R-HSA-74947

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

photoreceptor disc membrane, cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Visual phototransduction (Homo sapiens)
        
        The phototransduction cascade (Homo sapiens)
        
        Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
        
        p-MII:SAG dissociates to p-RHO and SAG (Homo sapiens)

General

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Loss of all-trans-retinal (atRAL) is followed by dissociation of arrestin (SAG) from p-RHO. RHO is then available for covalent binding to 11-cis-retinal (11cRAL), supplied by the retinal pigment epithelium, to regenerate rhodopsin. SAG is capable of binding weakly to rhodopsin, so the dissociation in some rhodopsins may occur after regeneration (Baumann & Bender 1973).

Literature References

PubMed ID	Title	Journal	Year
4772407	Kinetics of rhodopsin bleaching in the isolated human retina Baumann, C, Bender, S	J. Physiol. (Lond.)	1973

Participants

Input

p-RHO:SAG [photoreceptor disc membrane] (Homo sapiens)

Output

Participant Of

hasEvent

Inactivation, recovery and regulation of the phototransduction cascade

Inferred From

p-MII:Sag dissociates to p-Rho and Sag (Bos taurus)

Authored

Carleton, KL (2003-07-31)

Reviewed

Makino, C (2013-04-11)

Created

Carleton, KL (2003-07-31)