p-MII:SAG dissociates to p-RHO and SAG

Stable Identifier
R-HSA-74947
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
photoreceptor disc membrane, cytosol
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p-MII:SAG dissociates to p-RHO and SAG
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Loss of all-trans-retinal (atRAL) is followed by dissociation of arrestin (SAG) from p-RHO. RHO is then available for covalent binding to 11-cis-retinal (11cRAL), supplied by the retinal pigment epithelium, to regenerate rhodopsin. SAG is capable of binding weakly to rhodopsin, so the dissociation in some rhodopsins may occur after regeneration (Baumann & Bender 1973).

Literature References
PubMed ID Title Journal Year
4772407 Kinetics of rhodopsin bleaching in the isolated human retina

Baumann, C, Bender, S

J. Physiol. (Lond.) 1973
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Inferred From
p-MII:Sag dissociates to p-Rho and Sag (Bos taurus)
Authored
Carleton, KL  (2003-07-31)
Reviewed
Makino, C  (2013-04-11)
Created
Carleton, KL  (2003-07-31)
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