Reactome | Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz

Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz

Stable Identifier

R-HSA-749446

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz

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Gz is predominantly expressed in the nervous system and platelets. Gz interacts with receptors for many neurotransmitters and neuropeptides, including the adenosine A1, alpha2-adrenergic, dopamine D2, 5-HT1A, muscarinic M2, substance P, and all types of opioid receptors. In addition, Gz is capable of transducing signals from receptors such as the C5a and formyl peptide receptors. All these receptors can also signal via Gi. (Ho & Wong 2001).

Literature References

PubMed ID	Title	Journal	Year
10954748	Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs Blendy, JA, Lucki, I, Manning, D, Dalvi, A, Yang, J, Poncz, M, Kowalska, MA, Brass, LF, O'Brien, PJ, Wu, J, Prevost, N	Proc Natl Acad Sci U S A	2000
11313909	G(z) signaling: emerging divergence from G(i) signaling Ho, MK, Wong, YH	Oncogene	2001