GNAT1-GDP binds to GNB1:GNGT1

Stable Identifier
R-HSA-74882
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once transducin alpha subunit (GNAT1) is deactivated by hydrolysis of bound GTP to GDP, it reassociates with transducin beta:gamma subunits (GNB1:GNGT1) to form inactive transducin (Gt-GDP). A stoichiometric overabundance of GNB1:GNGT1 facilitates the reassociation event. The details for this event were revealed in bovine experiments (Clark et al. 2006, Fung et al. 1981).

Literature References
PubMed ID Title Journal Year
16895762 Transducin subunit stoichiometry and cellular distribution in rod outer segments

Clack, JW, Springmeyer, ML, Clark, CR, Witzmann, FA

Cell Biol. Int. 2006
6264430 Flow of information in the light-triggered cyclic nucleotide cascade of vision

Fung, BK, Hurley, JB, Stryer, L

Proc. Natl. Acad. Sci. U.S.A. 1981
Participants
Participant Of
Inferred From
Authored
Reviewed
Created