Reactome | RDH10,11 oxidise 11cROL to 11cRAL

RDH10,11 oxidise 11cROL to 11cRAL

Stable Identifier

R-HSA-74872

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

RDHs oxidise 11-cis-retinol to 11-cis-retinal

ReviewStatus

5/5

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Using NADP+ as cofactor, several members of the short-chain dehydrogenases/reductases (SDR) family can (reversibly) catalyse the oxidation of 11-cis-retinol (11cROL) to 11-cis-retinal (11cRAL) in retinal pigment epithelium (RPE) cells. Retinol dehydrogenases 10 and 11 (RDH10 and 11) are two such members utilizing the cofactor NADP+ (Wu et al. 2002, Kedishvili et al. 2002 respectively). Cellular retinaldehyde-binding protein (RLBP1), the protein bound to 11cRAL in RPE, is not present in photoreceptor cells.

Literature References

PubMed ID	Title	Journal	Year
12407145	Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE Rohrer, B, Wu, BX, Ma, JX, Fan, J, Chen, Y, Chen, Y, Crouch, RK	Invest. Ophthalmol. Vis. Sci.	2002
12036956	Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1) Belyaeva, OV, Lin, DW, Nelson, PS, Chumakova, OV, Chetyrkin, SV, Matsumura, M, Lapshina, EA, Kedishvili, NY	J. Biol. Chem.	2002