p-Y-IRS1,p-Y-IRS2 bind PI3K

Stable Identifier
R-HSA-74737
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IRS1, IRS2 and IRS3 are all known to bind the regulatory subunit of PI3K via its SH2 domain, an interaction that itself activates the kinase activity of the PI3K catalytic subunit (Rivachandran et al. 2001).

Literature References
PubMed ID Title Journal Year
11063744 Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin

Ravichandran, LV, Esposito, DL, Chen, J, Quon, MJ

J. Biol. Chem. 2001
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