p-Y-IRS1,p-Y-IRS2 bind PI3K

Stable Identifier
R-HSA-74737
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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p-Y-IRS1,p-Y-IRS2 bind PI3K
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IRS1, IRS2 and IRS3 are all known to bind the regulatory subunit of PI3K via its SH2 domain, an interaction that itself activates the kinase activity of the PI3K catalytic subunit (Rivachandran et al. 2001).
Literature References
PubMed ID Title Journal Year
11063744 Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin

Esposito, DL, Ravichandran, LV, Chen, J, Quon, MJ

J. Biol. Chem. 2001
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Orthologous Events
p-Y-IRS1,p-Y-IRS2 bind PI3K (Bos taurus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Canis familiaris)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Drosophila melanogaster)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Gallus gallus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Sus scrofa)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Xenopus tropicalis)
Authored
Created
Bevan, AP  (2003-07-31)
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