Insulin degradation

Stable Identifier
R-HSA-74730
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
endosome
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Insulin degradation
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At the beginning of this reaction, 1 molecule of 'insulin' is present.

This reaction takes place in the 'endosome' and is mediated by the 'insulysin activity of IDA (insulin degrading activity' of 'IDA (insulin degrading activity)'.

Literature References
PubMed ID Title Journal Year
9793760 Insulin degradation: progress and potential.

Duckworth, WC, Bennett, RG, Hamel, FG

Endocr Rev 1998
3061785 Insulin degradation: mechanisms, products, and significance.

Duckworth, WC

Endocr Rev 1989
8682206 Endosomal proteolysis of internalized proteins.

Bergeron, JJ, Authier, F, Posner, BI

FEBS Lett 1996
Participants
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as an event of
Catalyst Activity

endopeptidase activity of IDA [endosome lumen]

Physical Entity
IDA [endosome lumen] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Created
Bevan, AP  (2003-07-31)
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