Dissociation of IRS-P from insulin receptor

Stable Identifier
R-HSA-74712
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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At the beginning of this reaction, 1 molecule of 'phospho-IRS:activated insulin receptor' is present. At the end of this reaction, 1 molecule of 'activated insulin receptor', and 1 molecule of 'phospho-IRS' are present.

This reaction takes place on the 'internal side of plasma membrane'. In Fao or NIH3T3 cells stably expressing IR, overexpression of PKCζ enhances the dissociation from IR and decrease in IRS1 tyrosine phosphorylation caused by prolonged insulin stimulation (Riu et al. 2001, Ravichandran et al. 2001).

Literature References
PubMed ID Title Journal Year
11063744 Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin

Ravichandran, LV, Esposito, DL, Chen, J, Quon, MJ

J. Biol. Chem. 2001
11278339 Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

Liu, YF, Paz, K, Herschkovitz, A, Alt, A, Tennenbaum, T, Sampson, SR, Ohba, M, Kuroki, T, LeRoith, D, Zick, Y

J. Biol. Chem. 2001
Participants
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