Reactome | Dissociation of IRS-P from insulin receptor

Dissociation of IRS-P from insulin receptor

Stable Identifier

R-HSA-74712

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Dissociation of IRS-P from insulin receptor

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At the beginning of this reaction, 1 molecule of 'phospho-IRS:activated insulin receptor' is present. At the end of this reaction, 1 molecule of 'activated insulin receptor', and 1 molecule of 'phospho-IRS' are present.

This reaction takes place on the 'internal side of plasma membrane'. In Fao or NIH3T3 cells stably expressing IR, overexpression of PKCÎ¶ enhances the dissociation from IR and decrease in IRS1 tyrosine phosphorylation caused by prolonged insulin stimulation (Riu et al. 2001, Ravichandran et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
15069075	Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1 Moeschel, K, Schleicher, ED, Weigert, C, Kalbacher, H, Lammers, R, Lehmann, R, Voelter, W, Beck, A, Häring, HU	J Biol Chem	2004
11063744	Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin Esposito, DL, Ravichandran, LV, Chen, J, Quon, MJ	J. Biol. Chem.	2001