Binding of IRS to insulin receptor

Stable Identifier
R-HSA-74707
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Binding of IRS to insulin receptor
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Using receptor mutagenesis studies it is known that IRS1 via its PTB domain binds to the insulin receptor at the juxtamembrane region at tyrosine 972. The interaction is further stabilized by the PH domain of IRS1 which interacts with the phospholipids of the plasma membrane. This allows the receptor to phosphorylate IRS1 on up to 13 of its tyrosine residues (Tavare and Denton 1998, Duan et al.2004).

Literature References
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
GRB10:INSR [plasma membrane] (Homo sapiens)
Active Unit
GRB10 [cytosol]
Orthologous Events
Binding of IRS to insulin receptor (Bos taurus)
Binding of IRS to insulin receptor (Canis familiaris)
Binding of IRS to insulin receptor (Danio rerio)
Binding of IRS to insulin receptor (Gallus gallus)
Binding of IRS to insulin receptor (Mus musculus)
Binding of IRS to insulin receptor (Rattus norvegicus)
Binding of IRS to insulin receptor (Sus scrofa)
Binding of IRS to insulin receptor (Xenopus tropicalis)
Created
Bevan, AP  (2003-07-31)
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