Binding of IRS to insulin receptor

Stable Identifier
R-HSA-74707
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Using receptor mutagenesis studies it is known that IRS1 via its PTB domain binds to the insulin receptor at the juxtamembrane region at tyrosine 972. The interaction is further stabilized by the PH domain of IRS1 which interacts with the phospholipids of the plasma membrane. This allows the receptor to phosphorylate IRS1 on up to 13 of its tyrosine residues (Tavare and Denton 1998, Duan et al.2004).

Participants
Participant Of
hasEvent
This event is regulated
Orthologous Events
Created