Reactome | p-Y427-SHC1 [cytosol]

p-Y427-SHC1 [cytosol]

Stable Identifier

R-HSA-74684

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SHC transforming protein

Icon

Locations in the PathwayBrowser for interactor UniProt:P32927 CSF2RB

Expand all

External Reference Information

External Reference

UniProt:P29353 SHC1

Gene Names

SHC1, SHC, SHCA

Chain

chain:1-583

Reference Genes

BioGPS Gene:6464 SHC1

COSMIC (genes):SHC1 SHC1

CTD Gene:6464 SHC1

dbSNP Gene:6464 SHC1

ENSEMBL:ENSG00000160691 SHC1

ENSEMBL_homo_sapiens_GENE:ENSG00000160691.19 SHC1

HGNC:10840 SHC1

KEGG Gene (Homo sapiens):6464 SHC1

Monarch:6464 SHC1

NCBI Gene:6464 SHC1

OMIM:600560 SHC1

UCSC:P29353 SHC1

Reference Transcript

Other Identifiers

11727363_a_at

11727364_s_at

11732136_a_at

11758297_s_at

16693891

16693898

201469_PM_s_at

201469_s_at

214853_PM_s_at

214853_s_at

2436980

2436981

2436982

2436983

2436984

2436986

2436987

2436988

2436989

2436990

2436991

2436992

2436995

2436996

2436997

2436998

2436999

2437000

2437002

2437003

2437004

2437005

2437006

2437007

2437009

2437010

2437011

2437012

2437013

2437014

2437015

2437016

2437018

3759015

3759016

38118_at

6464

7920600

A_23_P200443

A_24_P68585

GE59385

GO:0001525

GO:0001784

GO:0005068

GO:0005154

GO:0005158

GO:0005159

GO:0005168

GO:0005515

GO:0005543

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0007010

GO:0007155

GO:0007173

GO:0007507

GO:0008284

GO:0008286

GO:0008289

GO:0012501

GO:0016525

GO:0023052

GO:0030036

GO:0030971

GO:0035556

GO:0042127

GO:0042742

GO:0043066

GO:0043226

GO:0043410

GO:0045892

GO:0045893

GO:0046875

GO:0048009

GO:0048408

GO:0048856

GO:0060090

GO:0070161

GO:0070374

GO:0070435

GO:0071363

GO:0071864

GO:0090322

GO:0098542

GO:0098609

HMNXSV003029143

HMNXSV003056955

Hs.81972.0.A1_3p_a_at

Hs.81972.1.A1_3p_a_at

ILMN_1701967

ILMN_1721022

ILMN_1812570

PH_hs_0030190

TC01006381.hg

U73377_at

Participates

as an output of

as a component of

as an input of

Other forms of this molecule

p-Y349,Y350-SHC1 [cytosol]

p-Y349,Y350,Y427-SHC1 [cytosol]

SHC1 [cytosol]

p-Y-SHC1 [cytosol]

Inferred To

Ghost homologue of p-Y427-SHC1 [cytosol] (Caenorhabditis elegans)

Ghost homologue of p-Y427-SHC1 [cytosol] (Danio rerio)

Ghost homologue of p-Y427-SHC1 [cytosol] (Xenopus tropicalis)

phospho-Shc1 [cytosol] (Mus musculus)

phospho-Shc1 [cytosol] (Rattus norvegicus)

phospho-SHC1 [cytosol] (Bos taurus)

phospho-SHC1 [cytosol] (Canis familiaris)

phospho-SHC1 [cytosol] (Gallus gallus)

phospho-SHC1 [cytosol] (Sus scrofa)

phospho-Shc [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O4'-phospho-L-tyrosine at 427

Coordinate

427

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001123513.1, NP_003020.2, NP_892113.4, NP_001123512.1, NP_001189788.1

OpenTargets

ENSG00000160691

HPA

ENSG00000160691-SHC1

ZINC - Substances

SHC1_HUMAN

GeneCards

P29353

ZINC target

P29353

Ensembl

ENST00000368450, ENST00000448116, ENSP00000401303, ENST00000368445, ENST00000368453, ENSP00000357438, ENSP00000357430, ENSG00000160691, ENSP00000357435

PRO

P29353

Pharos - Targets

P29353

ZINC - Predictions - Purchasable

SHC1_HUMAN

PDB

1MIL, 1SHC, 1N3H, 4XWX, 6DM4, 1OY2, 5CZI, 1QG1, 4JMH, 1TCE, 2L1C

Interactors (40)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.976	44
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.976	33
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.856	9
UniProt:P62994 Grb2	3	Grb2 [cytosol] (R-RNO-55929) Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-74686)	0.822	5
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.821	16
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.816	6
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.77	5
UniProt:P21860 ERBB3			0.762	7
UniProt:O95782 AP2A1	5	AP2A1 [endolysosome membrane] (R-HSA-6784829) AP2A1 [endocytic vesicle membrane] (R-HSA-416641) AP2A1 [plasma membrane] (R-HSA-177494) AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449) AP2A1 [cytosol] (R-HSA-182143)	0.725	6
UniProt:O94973 AP2A2	6	AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [plasma membrane] (R-HSA-177502) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155)	0.643	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.643	5
UniProt:Q16832 DDR2	1	DDR2 [plasma membrane] (R-HSA-211419)	0.632	3
UniProt:Q15303 ERBB4			0.609	6
UniProt:Q12774 ARHGEF5	1	ARHGEF5 [cytosol] (R-HSA-8873909)	0.597	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.589	6
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.573	2
UniProt:Q9UM73 ALK	20	p-7Y ALK T1087I [plasma membrane] (R-HSA-9723885) p-7Y ALK R1061Q [plasma membrane] (R-HSA-9723884) p-7Y ALK L1196M [plasma membrane] (R-HSA-9700464) p-7Y ALK M1166R [plasma membrane] (R-HSA-9700477) p-Y ALK S1206C [plasma membrane] (R-HSA-9715292) p- 7Y ALK L1122V [plasma membrane] (R-HSA-9715294) p-7Y ALK E1384K [plasma membrane] (R-HSA-9715285) p-7Y ALK L1196Q [plasma membrane] (R-HSA-9700476) p-7Y ALK V1180L [plasma membrane] (R-HSA-9715289) p-7Y ALK G1201R [plasma membrane] (R-HSA-9701860) p-7Y ALK I1171T [plasma membrane] (R-HSA-9700489) p-7Y ALK R1275L [plasma membrane] (R-HSA-9699800) p-7Y ALK F1174C [plasma membrane] (R-HSA-9699821) p-7Y ALK F1174V [plasma membrane] (R-HSA-9699921) p-7Y ALK M1166N [plasma membrane] (R-HSA-9723299) p-7Y ALK M1166T [plasma membrane] (R-HSA-9700486) p-7Y ALK Y1239H [plasma membrane] (R-HSA-9715290) p-7Y ALK R1275* [plasma membrane] (R-HSA-9699915) p-7Y ALK I1171S [plasma membrane] (R-HSA-9714063) p-7Y ALK G1128S [plasma membrane] (R-HSA-9700462)	0.569	3
UniProt:P35968 KDR	5	p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane] (R-HSA-9673636) VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane] (R-HSA-9673613) p-Y801,Y1054,Y1175-KDR [plasma membrane] (R-HSA-9860484) VEGFR2 [plasma membrane] (R-HSA-195382) p-6Y-VEGFR2 [plasma membrane] (R-HSA-4420103)	0.564	2
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.564	2
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.564	2
UniProt:Q13137 CACO2			0.553	3
UniProt:P16573	11	Ceacam1 [extracellular region] (R-RNO-8941137-3) Ceacam1 [plasma membrane] (R-RNO-8940816-3) Ceacam1 [extracellular region] (R-RNO-8870747-3) Ceacam1 [extracellular region] (R-RNO-8870766-3) Ceacam1 [extracellular region] (R-RNO-8870757-3) Ceacam1 [extracellular region] (R-RNO-8870759-3) Ceacam1 [plasma membrane] (R-RNO-197706-3) Ceacam1 [specific granule membrane] (R-RNO-6806076-3) Ceacam1 [specific granule membrane] (R-RNO-6799528) Ceacam1 [plasma membrane] (R-RNO-197701) Ceacam1 [tertiary granule membrane] (R-RNO-6800953)	0.544	3
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.544	2
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.544	2
UniProt:P26954	4	phospho-Csf2rb2 [plasma membrane] (R-MMU-914092) phospho-Csf2rb2 [plasma membrane] (R-MMU-914170) Csf2rb2 [plasma membrane] (R-MMU-879960) phospho-Csf2rb2 [plasma membrane] (R-MMU-912312)	0.544	4
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166)	0.527	3
UniProt:Q05655 PRKCD	12	PRKCD(1-676) [nucleoplasm] (R-HSA-450606) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) p-T507-PRKCD [cytosol] (R-HSA-5218746) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) PRKCD(330-676) [cytosol] (R-HSA-212551) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD [cytosol] (R-HSA-58200)	0.527	3
UniProt:Q9H706 GARE1			0.527	4
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.527	2
UniProt:P32927 CSF2RB	6	CSF2RB S271L [plasma membrane] (R-HSA-5688879) p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863)	0.527	4
UniProt:Q8TF42 UBS3B			0.527	3
UniProt:Q38SD2 LRRK1			0.527	3
UniProt:Q93008 USP9X	1	USP9X [cytosol] (R-HSA-870499)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	6
UniProt:P03495 NS1			0.508	2
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.483	3
UniProt:Q02763 TEK	2	TEK [plasma membrane] (R-HSA-197755) p-5Y,S1119-TEK [plasma membrane] (R-HSA-204772)	0.462	2
UniProt:Q08345-1 DDR1			0.462	4
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [Golgi membrane] (R-HSA-3008805) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.462	2
UniProt:A9UF07 A9UF07			0.462	4