Reactome | Calcium binds calmodulin

Calcium binds calmodulin

Stable Identifier

R-HSA-74448

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        Calcium binds calmodulin (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Signaling by the B Cell Receptor (BCR) (Homo sapiens)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
      - Calcium binds calmodulin (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - C-type lectin receptors (CLRs) (Homo sapiens)
    - CLEC7A (Dectin-1) signaling (Homo sapiens)
      - CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
        
        Calcium binds calmodulin (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated Ca+2 mobilization (Homo sapiens)
      - Calcium binds calmodulin (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calcium binds calmodulin (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calcium binds calmodulin (Homo sapiens)
      - Visual phototransduction (Homo sapiens)
        
        The phototransduction cascade (Homo sapiens)
        
        Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
        
        Calcium binds calmodulin (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - VEGFR2 mediated cell proliferation (Homo sapiens)
        
        Calcium binds calmodulin (Homo sapiens)

General

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Upon increase in calcium concentration, calmodulin (CaM) is activated by binding to four calcium ions (Crouch and Klee 1980).

Participants

Input

Output

CALM1:4xCa2+ [cytosol] (Homo sapiens)

Participant Of

hasEvent

Inferred From

Calcium binds calmodulin (Bos taurus)

Authored

Le Novere, N (2004-03-31)

Jassal, B (2004-03-31)

Reviewed

Rush, MG (2008-01-11)

Created

Carleton, KL (2003-07-31)