SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the antiport of GDP-mannose into the Golgi lumen in exchange for GMP (Suda T et al, 2004; Ishida N et al, 2005).

Literature References
PubMed ID Title Journal Year
15607426 Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family

Ishida, N, Miyatake, S, Sanai, Y, Kawakita, M, Aoki, K, Kuba, T

Genomics 2005
15082721 Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection

Suzuki, M, Kamiyama, S, Aoki, T, Suda, T, Kikuchi, N, Narimatsu, H, Nishihara, S, Nakayama, K, Jigami, Y

J Biol Chem 2004
Catalyst Activity

nucleotide-sugar transmembrane transporter activity of SLC35D2 [Golgi membrane]

Orthologous Events
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