Cytosolic xanthine dehydrogenase (XDH) in its oxidase form catalyzes the reaction of hypoxanthine with H2O and oxygen to form xanthine and H2O2. The active form of the enzyme is a dimer (Saksela and Raivio 1996; Yamaguchi et al. 2007). The enzyme is said to occur predominantly in its dehydrogenase form, catalyzing the reaction of hypoxanthine with NAD+ to form xanthine and to be converted to the oxidase form annotated here in response to stress (Ichida et al. 2012).
Amaya, Y, Nishino, T, Ichida, K, Okamoto, K
Raivio, KO, Saksela, M
Yamaguchi, Y, Nishino, T, Matsumura, T, Ichida, K, Okamoto, K
hypoxanthine oxidase activity of XDH dimer [cytosol]
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