XDH oxidizes hypoxanthine to form xanthine

Stable Identifier
R-HSA-74247
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Hypoxanthine + H2O + O2 => Xanthine + H2O2
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic xanthine dehydrogenase (XDH) in its oxidase form catalyzes the reaction of hypoxanthine with H2O and oxygen to form xanthine and H2O2. The active form of the enzyme is a dimer (Saksela and Raivio 1996; Yamaguchi et al. 2007). The enzyme is said to occur predominantly in its dehydrogenase form, catalyzing the reaction of hypoxanthine with NAD+ to form xanthine and to be converted to the oxidase form annotated here in response to stress (Ichida et al. 2012).

Participants
Participates
Catalyst Activity

hypoxanthine oxidase activity of XDH dimer [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!