Hypoxanthine + H2O + O2 => Xanthine + H2O2

Stable Identifier
R-HSA-74247
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Hypoxanthine + H2O + O2 => Xanthine + H2O2
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic xanthine dehydrogenase (XDH) catalyzes the reaction of hypoxanthine with H2O and oxygen to form xanthine and H2O2. The active form of the enzyme is a dimer (Saksela and Raivio 1996; Yamaguchi et al. 2007).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
xanthine oxidase activity of XDH dimer [cytosol]
Physical Entity
XDH dimer [cytosol]
Activity
xanthine oxidase activity (0004855)
Orthologous Events
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Caenorhabditis elegans)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Canis familiaris)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Danio rerio)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Dictyostelium discoideum)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Drosophila melanogaster)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Gallus gallus)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Mus musculus)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Rattus norvegicus)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Sus scrofa)
Hypoxanthine + H2O + O2 => Xanthine + H2O2 (Xenopus tropicalis)
Created
Jassal, B  (2003-07-17)