Reactome | SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen

SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen

Stable Identifier

R-HSA-742345

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen, cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        GDP-fucose biosynthesis (Homo sapiens)
        
        SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen (Homo sapiens)

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SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen

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The human gene SLC35C1 encodes the GDP-fucose transporter FUCT1. It resides on the Golgi membrane and mediates the transport of GDP-fucose (GDP-Fuc) formed from a de novo pathway and/or a salvage pathway into the Golgi lumen. Defects in SLC35C1 causes the congenital disorder of glycosylation type 2C, also known as leukocyte adhesion deficiency type II (LAD2) (Lubke et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11326280	Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency Lübke, T, Marquardt, T, Etzioni, A, Hartmann, E, von Figura, K, Körner, C	Nat Genet	2001