Mitochondrial succinyl-CoA:3-ketoacid coenzyme A transferases 1 and 2 (OXCT1 and OXCT2) are key enzymes for the metabolism of ketone bodies, catalysing the first rate-limiting step of ketone body utilisation in peripheral tissues. In dimeric form, they mediate the transfer of a CoA moiety from succinyl-CoA (SUCC-CoA) to acetoacetate (ACA) to form acetoacetyl-CoA (ACA-CoA) and succinate (SUCCA) (Kassovska-Bratinova et al. 1996, Tanaka et al. 2002). ACA-CoA can be converted to acetyl-CoA which can be utilised by the tricarboxylic acid cycle for energy production.
Kondo, N, Pérez-Cerda, C, Kassovska-Bratinova, S, Vobecky, S, Fukao, T, Ugarte, M, Robert, MF, Duncan, AM, Mitchell, GA, Chartrand, C, Song, XQ, Chen, HS
Kohroki, J, Tanaka, H, Nishimune, Y, Onishi, M, Iguchi, N
3-oxoacid CoA-transferase activity of OXCT dimers [mitochondrial matrix]
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