SLC35B2,3 transport cytosolic PAPS to Golgi lumen

Stable Identifier
Reaction [transition]
Homo sapiens
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The human gene SLC35B2 encodes the adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPST1) (Ozeran et al. 1996, Kamiyama et al. 2003). In human tissues, PAPST1 is highly expressed in the placenta and pancreas and present at lower levels in the colon and heart. The human gene SLC35B3 encodes a human PAPS transporter gene that is closely related to PAPST1. Called PAPST2, it is predominantly expressed in the colon (Kamiyama et al. 2006). Both proteins can transport PAPS from the cytosol to the Golgi lumen.

Literature References
PubMed ID Title Journal Year
16492677 Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2

Irimura, T, Sasaki, N, Kannagi, R, Kamiyama, S, Goda, E, Narimatsu, H, Nishihara, S, Ui-Tei, K, Jigami, Y, Saigo, K

J Biol Chem 2006
12716889 Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporter

Watanabe, M, Suda, T, Ueda, R, Narimatsu, H, Goto, S, Saigo, K, Chiba, Y, Suzuki, M, Toyoda, H, Kamiyama, S, Okubo, R, Kikuchi, N, Nishihara, S, Jigami, Y

J Biol Chem 2003
8619989 Identification and partial purification of PAPS translocase

Schwartz, NB, Ozeran, JD, Westley, J

Biochemistry 1996
Event Information
Catalyst Activity

3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity of SLC35B2,3 [Golgi membrane]

Orthologous Events
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