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PDE6 [photoreceptor disc membrane]
Stable Identifier
R-HSA-74055
Type
Complex
Species
Homo sapiens
Compartment
photoreceptor disc membrane
Synonyms
Phosphodiesterase 6, cGMP-PDE
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
The phototransduction cascade (Homo sapiens)
Activation of the phototransduction cascade (Homo sapiens)
GNAT1-GTP binds PDE6 and activates it (Homo sapiens)
GNAT1-GTP:PDE6 [photoreceptor disc membrane] (Homo sapiens)
PDE6 [photoreceptor disc membrane] (Homo sapiens)
PDE6 [photoreceptor disc membrane] (Homo sapiens)
PDE6 hydrolyses cGMP to GMP (Homo sapiens)
GNAT1-GTP:PDE6 [photoreceptor disc membrane] (Homo sapiens)
PDE6 [photoreceptor disc membrane] (Homo sapiens)
Inactivation, recovery and regulation of the phototransduction cascade (Homo sapiens)
GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)
GNAT1-GTP:PDE6 [photoreceptor disc membrane] (Homo sapiens)
PDE6 [photoreceptor disc membrane] (Homo sapiens)
PDE6 [photoreceptor disc membrane] (Homo sapiens)
General
cGMP selective hydrolase
Literature References
PubMed ID
Title
Journal
Year
6286681
Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments
Stryer, L
,
Hurley, JB
J Biol Chem
1982
Participants
components
PDE6A(2-860) [photoreceptor disc membrane]
(Homo sapiens)
PDE6B(1-851) [photoreceptor disc membrane]
(Homo sapiens)
x 2
PDE6G [photoreceptor disc membrane]
(Homo sapiens)
Participates
as an input of
GNAT1-GTP binds PDE6 and activates it (Homo sapiens)
as an output of
GNAT1-GTP hydrolyses its bound GTP to GDP (Homo sapiens)
as a component of
GNAT1-GTP:PDE6 [photoreceptor disc membrane] (Homo sapiens)
Inferred To
PDE6 [photoreceptor disc membrane]
(Bos taurus)
PDE6 [photoreceptor disc membrane]
(Canis familiaris)
PDE6 [photoreceptor disc membrane]
(Mus musculus)
PDE6 [photoreceptor disc membrane]
(Rattus norvegicus)
PDE6 [photoreceptor disc membrane]
(Sus scrofa)
PDE6 [photoreceptor disc membrane]
(Xenopus tropicalis)
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