Resynthesis of excised residue by POLB

Stable Identifier
R-HSA-73932
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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POLB (DNA polymerase beta) mediates DNA synthesis that fills the gap left after excision of the abasic sugar-phosphate residue, using the undamaged strand as a template (Kubota et al. 1996).

Literature References
PubMed ID Title Journal Year
8978692 Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

Kubota, Y, Nash, RA, Klungland, A, Schär, P, Barnes, DE, Lindahl, T

EMBO J 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA-directed DNA polymerase activity of LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created