Resynthesis of excised residue by POLB

Stable Identifier
R-HSA-73932
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Resynthesis of excised residue by POLB
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POLB (DNA polymerase beta) mediates DNA synthesis that fills the gap left after excision of the abasic sugar-phosphate residue, using the undamaged strand as a template (Kubota et al. 1996).

Literature References
PubMed ID Title Journal Year
8978692 Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

Lindahl, T, Kubota, Y, Nash, RA, Klungland, A, Schär, P, Barnes, DE

EMBO J 1997
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Catalyst Activity

DNA-directed DNA polymerase activity of LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm]

Physical Entity
LIG3:XRCC1:POLB:SSB-gap-dsDNA [nucleoplasm] (Homo sapiens)
Activity
DNA-directed DNA polymerase activity (GO:0003887)
Orthologous Events
Resynthesis of excised residue by POLB (Bos taurus)
Resynthesis of excised residue by POLB (Canis familiaris)
Resynthesis of excised residue by POLB (Danio rerio)
Resynthesis of excised residue by POLB (Dictyostelium discoideum)
Resynthesis of excised residue by POLB (Mus musculus)
Resynthesis of excised residue by POLB (Rattus norvegicus)
Resynthesis of excised residue by POLB (Sus scrofa)
Resynthesis of excised residue by POLB (Xenopus tropicalis)
Authored
Matthews, L  (2004-01-29)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-01-29)
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