Reactome | LIG3-mediated DNA ligation via the single-nucleotide replacement pathway

LIG3-mediated DNA ligation via the single-nucleotide replacement pathway

Stable Identifier

R-HSA-73931

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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LIG3-mediated DNA ligation via the single-nucleotide replacement pathway

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After POLB (DNA polymerase beta) fills a single nucleotide gap created by the APEX1 and POLB-mediated excision of the apurinic/apyrimidinic (AP) site in the damaged DNA strand, LIG3 (DNA ligase 3), recruited to POLB-bound AP site by XRCC1, ligates the two DNA strand fragments, thus completing the base excision repair (Kubota et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8978692	Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. Kubota, Y, Nash, RA, Klungland, A, Schär, P, Barnes, DE, Lindahl, T	EMBO J	1997