LIG3-mediated DNA ligation via the single-nucleotide replacement pathway

Stable Identifier
R-HSA-73931
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After POLB (DNA polymerase beta) fills a single nucleotide gap created by the APEX1 and POLB-mediated excision of the apurinic/apyrimidinic (AP) site in the damaged DNA strand, LIG3 (DNA ligase 3), recruited to POLB-bound AP site by XRCC1, ligates the two DNA strand fragments, thus completing the base excision repair (Kubota et al. 1996).

Literature References
PubMed ID Title Journal Year
8978692 Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.

Kubota, Y, Nash, RA, Klungland, A, Schär, P, Barnes, DE, Lindahl, T

EMBO J 1997
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
DNA ligase activity of LIG3:XRCC1:POLB:SSB-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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