Depyrimidination

Stable Identifier
R-HSA-73928
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Depyrimidination
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Depyrimidination of a damaged nucleotide in DNA is mediated by a pyrimidine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar generating a free base and an abasic i.e. apurinic/apyrimidinic (AP) site (Lindahl and Wood 1999).
Literature References
PubMed ID Title Journal Year
10583946 Quality control by DNA repair

Lindahl, T, Wood, RD

Science 1999
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
depyrimidination (0045008)
Orthologous Events
Depyrimidination (Bos taurus)
Depyrimidination (Caenorhabditis elegans)
Depyrimidination (Canis familiaris)
Depyrimidination (Danio rerio)
Depyrimidination (Dictyostelium discoideum)
Depyrimidination (Drosophila melanogaster)
Depyrimidination (Gallus gallus)
Depyrimidination (Mus musculus)
Depyrimidination (Plasmodium falciparum)
Depyrimidination (Rattus norvegicus)
Depyrimidination (Saccharomyces cerevisiae)
Depyrimidination (Schizosaccharomyces pombe)
Depyrimidination (Sus scrofa)
Depyrimidination (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-09)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-02-03)
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