Depurination

Stable Identifier
R-HSA-73927
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Depurination
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Depurination of a damaged nucleotide is mediated by a purine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, generating a free base and an abasic i.e. apurinic/apyrimidinic (AP) site (Slupphaug et al. 1996, Parikh et al. 1998).
Literature References
PubMed ID Title Journal Year
8900285 A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

Kavli, B, Tainer, JA, Mol, CD, Krokan, HE, Arvai, AS, Slupphaug, G

Nature 1996
9724657 Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA

Tainer, JA, Bharati, S, Krokan, HE, Mol, CD, Slupphaug, G, Parikh, SS

EMBO J 1998
Participants
Events
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Event Information
Go Biological Process
depurination (0045007)
Orthologous Events
Depurination (Bos taurus)
Depurination (Canis familiaris)
Depurination (Danio rerio)
Depurination (Dictyostelium discoideum)
Depurination (Drosophila melanogaster)
Depurination (Gallus gallus)
Depurination (Mus musculus)
Depurination (Plasmodium falciparum)
Depurination (Rattus norvegicus)
Depurination (Saccharomyces cerevisiae)
Depurination (Schizosaccharomyces pombe)
Depurination (Sus scrofa)
Depurination (Xenopus tropicalis)
Authored
Matthews, L  (2004-02-09)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Matthews, L  (2004-02-03)
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