Depurination

Stable Identifier
R-HSA-73927
Type
Pathway
Species
Homo sapiens
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Depurination of a damaged nucleotide is mediated by a purine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, generating a free base and an abasic i.e. apurinic/apyrimidinic (AP) site (Slupphaug et al. 1996, Parikh et al. 1998).

Literature References
PubMed ID Title Journal Year
8900285 A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

Kavli, B, Tainer, JA, Mol, CD, Krokan, HE, Arvai, AS, Slupphaug, G

Nature 1996
9724657 Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA

Tainer, JA, Bharati, S, Krokan, HE, Mol, CD, Slupphaug, G, Parikh, SS

EMBO J 1998
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