acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+

Stable Identifier
R-HSA-73912
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Reduction of Acetoacetate to beta-Hydroxybutyrate
ReviewStatus
5/5
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acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
D-beta-hydroxybutyrate dehydrogenase tetramer (BDH1) in the mitochondrial matris catalyzes the reversible reaction of acetoacetate with NADH + H+ to form D-beta hydroxybutyrate and NAD+ (Marks et al. 1992).
Literature References
PubMed ID Title Journal Year
1639787 Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart

Duncan, TM, McIntyre, JO, Fleischer, S, Tempst, P, Erdjument-Bromage, H, Marks, AR

J Biol Chem 1992
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Event Information
Reverse Reaction
D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+ (Homo sapiens)
Catalyst Activity

3-hydroxybutyrate dehydrogenase activity of BDH1 tetramer [mitochondrial matrix]

Physical Entity
BDH1 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
3-hydroxybutyrate dehydrogenase activity (GO:0003858)
Orthologous Events
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Bos taurus)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Canis familiaris)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Danio rerio)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Drosophila melanogaster)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Gallus gallus)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Mus musculus)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Rattus norvegicus)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Schizosaccharomyces pombe)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Sus scrofa)
acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+ (Xenopus tropicalis)
Cross References
Rhea
Created
Gopinathrao, G  (2003-08-20)
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