Reactome | AIR + CO2 => CAIR

AIR + CO2 => CAIR

Stable Identifier

R-HSA-73806

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)

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The reversible carboxylation of 5'-phosphoribosyl-5-aminoimidazole (AIR) to form 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) is catalyzed by the phosphoribosylaminoimidazole carboxylase domain of the bifunctional protein "phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase" (PAICS) (Schild et al. 1990). The enzyme is an octamer (Li et al. 2007); it may associate in the cytosol with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
2183217	Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations Schild, D, Brake, AJ, Kiefer, MC, Young, D, Barr, PJ	Proc Natl Acad Sci USA	1990
18388293	Reversible compartmentalization of de novo purine biosynthetic complexes in living cells An, S, Kumar, R, Sheets, ED, Benkovic, SJ	Science	2008
17224163	Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis Li, SX, Tong, YP, Xie, XC, Wang, QH, Zhou, HN, Han, Y, Zhang, ZY, Gao, W, Li, SG, Zhang, XC, Bi, RC	J Mol Biol	2007