AIR + CO2 => CAIR

Stable Identifier
R-HSA-73806
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
Locations in the PathwayBrowser
General
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The reversible carboxylation of 5'-phosphoribosyl-5-aminoimidazole (AIR) to form 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) is catalyzed by the phosphoribosylaminoimidazole carboxylase domain of the bifunctional protein "phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase" (PAICS) (Schild et al. 1990). The enzyme is an octamer (Li et al. 2007); it may associate in the cytosol with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References
PubMed ID Title Journal Year
18388293 Reversible compartmentalization of de novo purine biosynthetic complexes in living cells

Benkovic, SJ, Sheets, ED, Kumar, R, An, S

Science 2008
2183217 Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations

Brake, AJ, Kiefer, MC, Schild, D, Young, D, Barr, PJ

Proc Natl Acad Sci USA 1990
17224163 Octameric structure of the human bifunctional enzyme PAICS in purine biosynthesis

Xie, XC, Wang, QH, Tong, YP, Li, SX, Li, SG, Zhang, ZY, Bi, RC, Zhou, HN, Zhang, XC, Gao, W, Han, Y

J Mol Biol 2007
Participants
Participates
Catalyst Activity

phosphoribosylaminoimidazole carboxylase activity of PAICS octamer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Created
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