Reactome | SAICAR => AICAR + Fumarate

SAICAR => AICAR + Fumarate

Stable Identifier

R-HSA-73800

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate

ReviewStatus

5/5

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The reversible conversion of 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) and fumarate is catalyzed by adenylosuccinate lyase. The active form of this enzyme is a cytosolic tetramer (Stone et al. 1993), and fluoresence microscopy of cultured human cells suggests that it may associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008). The enzyme also catalyzes the conversion of adenylosuccinate to adenosine 5'-monophosphate and fumarate. Humans lacking the enzyme accumulate dephosphorylated forms of both substrates, indicating that the enzyme mediates both reactions in vivo as well (Race et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10958654	Clinical, biochemical and molecular genetic correlations in adenylosuccinate lyase deficiency Marie, S, Vincent, MF, Race, V, Van den Berghe, G	Hum Mol Genet	2000
8366112	Expression, purification, and kinetic characterization of recombinant human adenylosuccinate lyase Zalkin, H, Stone, RL, Dixon, JE	J Biol Chem	1993
18388293	Reversible compartmentalization of de novo purine biosynthetic complexes in living cells Benkovic, SJ, Sheets, ED, Kumar, R, An, S	Science	2008